Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP1935Putative two somponent system sensor kinase protein; C-terminal region is similar to Mycobacterium tuberculosis hypothetical protein Rv0758 TR:P71815 (EMBL:Z80226) (485 aa) fasta scores: E(): 7.7e-38, 42.88% id in 471 aa, and to Bacillus halodurans two-component sensor histidine kinase BH0373 TR:Q9KFU8 (EMBL:AP001508) (459 aa) fasta scores: E(): 3.7e-29, 30.81% id in 464 aa. (519 aa)    
Predicted Functional Partners:
DIP1936
Putative two component system response regulator protein; Similar to Bacillus subtilis alkaline phosphatase synthesis transcriptional regulatory protein PhoP SW:PHOP_BACSU (P13792) (240 aa) fasta scores: E(): 1.3e-32, 42.37% id in 236 aa, and to Mycobacterium tuberculosis hypothetical PhoP-like protein Rv0757 TR:AAK45023 (EMBL:Z80226) (240 aa) fasta scores: E(): 3.2e-57, 66.37% id in 226 aa.
 
 
 0.957
DIP0064
Putative two-component system response regulator; Similar to Enterococcus faecalis VicR protein TR:Q9REA7 (EMBL:AJ012050) (283 aa) fasta scores: E(): 5.5e-35, 44.978% id in 229 aa, to Bacillus subtilis alkaline phosphatase synthesis transcriptional regulatory protein PhoP SW:PHOP_BACSU (P13792) (240 aa) fasta scores: E(): 3e-34, 42.918% id in 233 aa, and to Bacillus subtilis hypothetical sensory transduction protein YycF SW:YYCF_BACSU (P37478) (235 aa) fasta scores: E(): 1.8e-33, 43.478% id in 230 aa.
 
 
 0.877
DIP0286
Two-component regulatory protein; Similar to Klebsiella pneumoniae phosphate regulon transcriptional regulatory protein PhoB SW:PHOB_KLEPN (P45605) (229 aa) fasta scores: E(): 1.7e-25, 40.708% id in 226 aa, to Shigella dysenteriae phosphate regulon transcriptional regulatory protein PhoB SW:PHOB_SHIDY (P45606) (229 aa) fasta scores: E(): 6.5e-25, 40.265% id in 226 aa, and to Escherichia coli phosphate regulon transcriptional regulatory protein PhoB or B0399 or Z0497 or ECS0449 SW:PHOB_ECOLI (P08402) (229 aa) fasta scores: E(): 6.5e-25, 40.265% id in 226 aa.
 
 
 0.876
DIP0854
Putative two component system response regulator; Similar to Corynebacterium glutamicum response regulator TR:Q9F161 (EMBL:AF119221) (232 aa) fasta scores: E(): 2.4e-67, 79.31% id in 232 aa, and to Pseudomonas syringae transcriptional activator protein CopR SW:COPR_PSESM (Q02540) (227 aa) fasta scores: E(): 1.9e-32, 48% id in 225 aa.
 
 0.876
mtrA2
Putative two component system response regulator; Similar to Mycobacterium tuberculosis MtrA protein or Rv3246c or MTCY20B11.21c TR:Q50447 (EMBL:Z95121) (228 aa) fasta scores: E(): 7.6e-61, 70.66% id in 225 aa, and to Streptomyces coelicolor transcriptional regulatory protein AfsQ1 or 2SCK8.33c SW:AFQ1_STRCO (Q04942) (225 aa) fasta scores: E(): 2.4e-36, 45.2% id in 219 aa.
 
 
 0.875
regX3
Putative two component system response regulator; Similar to Mycobacterium tuberculosis sensory transduction protein RegX3 or Rv0491 or MT0510 or MTCY20G9.17 SW:RGX3_MYCTU (Q11156) (227 aa) fasta scores: E(): 4e-68, 80.97% id in 226 aa.
 
 
 0.872
odhA
2-oxoglutarate dehydrogenase, E1 and E2 components; Similar to Corynebacterium glutamicum 2-oxoglutarate dehydrogenase OdhA TR:P96746 (EMBL:D84102) (1257 aa) fasta scores: E(): 0, 77.37% id in 1242 aa, and to Mycobacterium leprae 2-oxoglutarate dehydrogenase, E1 and E2 components OdhA or ML1095 TR:Q9CC97 (EMBL:AL583920) (1260 aa) fasta scores: E(): 0, 59.37% id in 1253 aa. Similar in the N-terminus to Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2) SucB or B0727 or Z0881 or ECS0752 SW:ODO2_ECOLI (P07016) blastp scores: E(): 4 [...]
    
 0.736
DIP0021
Similar to Streptomyces coelicolor probable solute-binding lipoprotein SC8F11.05 TR:Q9KZH3 (EMBL:AL353864) (340 aa) fasta scores: E(): 2.8e-63, 54.98% id in 331 aa.
    
 
 0.724
DIP2160
Modular polyketide synthase; Similar to Streptomyces verticillus polyketide synthase BlmVIII (bleomycin biosynthesis) TR:Q9FB25 (EMBL:AF210249) (1841 aa) fasta scores: E(): 1.3e-72, 27.240% id in 1931 aa, and to Streptomyces noursei nystatin biosynthesis polyketide synthase Nys TR:Q9L4W3 (EMBL:AF263912) (11096 aa) fasta scores: E(): 4e-71, 33.107% id in 882 aa, and to Amycolatopsis mediterranei rifamycin polyketide synthase TR:Q9F847 (EMBL:AF262754) (1265 aa) fasta scores: E(): 7.7e-61, 31.042% id in 902 aa.
   
 
 0.568
DIP1939
Putative membrane protein; Similar to the N-terminus of Thermotoga maritima conserved hypothetical protein TM1156 TR:Q9X0P0 (EMBL:AE001773) (129 aa) fasta scores: E(): 5.1e-05, 39.34% id in 61 aa, and to the full length Bacillus subtilis hypothetical protein YvlC TR:O34719 (EMBL:AF017113) (65 aa) fasta scores: E(): 0.00018, 41.37% id in 58 aa.
  
   0.470
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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