STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1952Similar to Escherichia coli pyruvate dehydrogenase [cytochrome] PoxB SW:POXB_ECOLI (P07003) (572 aa) fasta scores: E(): 1.2e-100, 45.89% id in 573 aa, and to Streptomyces coelicolor pyruvate dehydrogenase SC1A9.19 TR:Q9ZBT3 (EMBL:AL034446) (580 aa) fasta scores: E(): 1.4e-132, 56.62% id in 581 aa; Belongs to the TPP enzyme family. (578 aa)    
Predicted Functional Partners:
ilvH
Similar to Mycobacterium tuberculosis acetolactate synthase small subunit IlvH or IlvN or Rv3002c or MT3082 or MTV012.16c SW:ILVH_MYCTU (O53249) (168 aa) fasta scores: E(): 1.3e-28, 54.77% id in 157 aa, and to Corynebacterium glutamicum (Brevibacterium flavum) acetohydroxy acid synthase, small subunit IlvN or LivS TR:Q57091 (EMBL:L09232) (172 aa) fasta scores: E(): 5.4e-47, 81.06% id in 169 aa.
 
 0.988
ackA
Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
    
 0.952
pyk
Pyruvate kinase; Similar to Corynebacterium glutamicum pyruvate kinase Pyk SW:KPYK_CORGL (Q46078) (475 aa) fasta scores: E(): 1.3e-146, 83.36% id in 469 aa, and to Bacillus psychrophilus pyruvate kinase Pyk SW:KPYK_BACPY (P51182) (586 aa) fasta scores: E(): 6.9e-64, 41.45% id in 480 aa.
  
 0.916
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.913
DIP0427
Similar to Clostridium acetobutylicum lactate dehydrogenase CAC3552 TR:AAK81477 (EMBL:AE007851) (320 aa) fasta scores: E(): 1.6e-36, 38.6% id in 316 aa, and to Bacillus subtilis L-lactate dehydrogenase Ldh or LctE SW:LDH_BACSU (P13714) (320 aa) fasta scores: E(): 2.9e-25, 33.95% id in 324 aa; Belongs to the LDH/MDH superfamily.
  
 0.912
pyc
Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.
     
 0.909
DIP2115
Putative aldehyde dehydrogenase; Similar to many eg. Acinetobacter spM-1. aldehyde dehydrogenase 1 Ald1 TR:Q9FDS1 (EMBL:AB042203) (503 aa) fasta scores: E(): 2.5e-143, 69.18% id in 503 aa, and to Alcaligenes eutrophus acetaldehyde dehydrogenase II AcoD SW:DHA2_ALCEU (P46368) (506 aa) fasta scores: E(): 1.8e-135, 66.39% id in 497 aa.
  
 0.908
aceE
Pyruvate dehydrogenase E1 component; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
     
 0.903
acyP
Similar to Mycobacterium tuberculosis putative acylphosphatase Rv2922.1c or MT2991 or MTCY338.11bc SW:ACYP_MYCTU (P56543) (93 aa) fasta scores: E(): 1.3e-14, 52.08% id in 96 aa, and to Escherichia coli putative acylphosphatase YccX or B0968 or Z1320 or ECS1052 SW:ACYP_ECOLI (P75877) (92 aa) fasta scores: E(): 1.2e-07, 43.82% id in 89 aa.
     
  0.900
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
  
 
 0.879
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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