STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1969Putative LacI-family transcriptional regulator; Similar to Escherichia coli raffinose operon repressor RafR SW:RAFR_ECOLI (P21867) (335 aa) fasta scores: E(): 1.5e-08, 24.52% id in 367 aa, and to Mycobacterium tuberculosis hypothetical protein Rv3575c TR:P96857 (EMBL:Z92774) (359 aa) fasta scores: E(): 1.8e-50, 45.82% id in 371 aa. (379 aa)    
Predicted Functional Partners:
DIP1970
SpoU rRNA Methylase family protein; Similar to Mycobacterium tuberculosis hypothetical protein Rv3579c TR:P96861 (EMBL:Z92774) (322 aa) fasta scores: E(): 1.1e-61, 58.33% id in 312 aa, and to Streptomyces coelicolor putative tRNA/rRNA methyltransferase SCD8A.09 TR:Q9L0Q5 (EMBL:AL160331) (314 aa) fasta scores: E(): 2.7e-57, 55.97% id in 318 aa; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.
       0.791
cysS1
Similar to Escherichia coli cysteinyl-tRNA synthetase CysS or B0526 SW:SYC_ECOLI (P21888) (461 aa) fasta scores: E(): 2.4e-70, 44.11% id in 467 aa, and to Mycobacterium tuberculosis cysteinyl-tRNA synthetase 1 Rv3580c SW:SYC1_MYCTU (P96862) (469 aa) fasta scores: E(): 1.4e-120, 64.57% id in 463 aa; Belongs to the class-I aminoacyl-tRNA synthetase family.
   
   0.781
DIP0021
Similar to Streptomyces coelicolor probable solute-binding lipoprotein SC8F11.05 TR:Q9KZH3 (EMBL:AL353864) (340 aa) fasta scores: E(): 2.8e-63, 54.98% id in 331 aa.
 
  
 0.775
ptsG
Similar to Corynebacterium glutamicum PTS system, glucose-specific IIABC component PtsG SWALL:PTGA_CORGL (SWALL:Q45298) (674 aa) fasta scores: E(): 2.8e-59, 44.91% id in 688 aa, and to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SWALL:PTSB_STAXY (SWALL:P51184) (480 aa) fasta scores: E(): 8e-26, 27.73% id in 494 aa.
  
  
 0.663
ispF
Putative 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).
       0.653
ispD
Putative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP).
       0.649
DIP1974
Putative CarD-like transcriptional factor; N-terminal region is similar to Mycobacterium tuberculosis putative transcriptional factor Rv3583c TR:O53568 (EMBL:AL022075) (162 aa) fasta scores: E(): 6.8e-38, 71.69% id in 159 aa, and to Mycobacterium leprae putative transcription factor ML0320 TR:Q9CCW7 (EMBL:AL583918) (165 aa) fasta scores: E(): 1.2e-37, 70.44% id in 159 aa.
       0.649
DIP2336
Similar to but longer than a family of hypothetical proteins eg. Deinococcus radiodurans conserved hypothetical protein DRB0052 SWALL:Q9RZR3 (EMBL:AE001826) (133 aa) fasta scores: E(): 8.8e-10, 43.75% id in 128 aa, and to Staphylococcus aureus (strain N315) hypothetical protein SA0607 or SAV0652 SWALL:Q99VW9 (EMBL:AP003131) (120 aa) fasta scores: E(): 1.3e-09, 42.73% id in 117 aa.
   
 
 0.635
DIP1435
Putative fructose-specific IIBC (PTS system) (pseudogene); HMMPfam hit to PF02378, Phosphotransferase system, EIIC.
   
 
 0.631
DIP0115
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 39.2 kDa protein SCH24.21c TR:Q9X8T5 (EMBL:AL049826) (360 aa) fasta scores: E(): 5e-111, 79.49% id in 356 aa.
      
 0.628
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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