STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP1994Hypothetical protein; Poor database matches. N-terminus is similar to the C-terminal region of Pseudomonas aeruginosa malonate decarboxylase alpha subunit PA0208 TR:Q9I6T0 (EMBL:AE004459) (554 aa) fasta scores: E(): 3.7, 32.31% id in 164 aa. (207 aa)    
Predicted Functional Partners:
DIP1995
Putative membrane protein; Weakly similar to the N-terminal regions of Mycobacterium leprae putative membrane protein ML0228 TR:O69526 (EMBL:AL023093) (432 aa) fasta scores: E(): 0.025, 25.15% id in 318 aa, and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3709 TR:AAK48067 (EMBL:AE007170) (397 aa) fasta scores: E(): 0.071, 23.51% id in 336 aa.
       0.842
DIP1996
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical protein Rv3605c TR:O06277 (EMBL:Z95557) (158 aa) fasta scores: E(): 1.3e-11, 39% id in 141 aa, and to Mycobacterium leprae hypothetical protein ML0227 TR:O69527 (EMBL:AL023093) (158 aa) fasta scores: E(): 5.6e-11, 36.73% id in 147 aa.
       0.842
folK
Putative 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; Similar to Escherichia coli 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FolK SW:HPPK_ECOLI (P26281) (158 aa) fasta scores: E(): 1.1e-11, 36.36% id in 154 aa, and to Mycobacterium tuberculosis 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase Rv3606c SW:HPPK_MYCTU (O06276) (188 aa) fasta scores: E(): 6e-23, 48.93% id in 141 aa.
       0.842
DIP1998
Putative dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin.
       0.842
DIP1999
Putative dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
       0.842
DIP1993
Conserved hypothetical protein; C-terminus is similar to the C-terminal region of Lotus japonicus pantoate--beta-alanine ligase precursor PanC SW:PANC_LOTJA (O24035) (307 aa) fasta scores: E(): 4.4e-07, 28.11% id in 217 aa. Similar to the Mycobacterium tuberculosis pantoate--beta-alanine ligase Rv3602c SW:PANC_MYCTU (O06280) (309 aa) fasta scores: E(): 4.7e-19, 38.62% id in 277 aa; Belongs to the pantothenate synthetase family.
     
 0.831
DIP2328
Conserved integral membrane protein; Similar to Clostridium acetobutylicum uncharacterized conserved membrane protein, similar to Mdr CAC0829 SWALL:AAK78805 (EMBL:AE007599) (308 aa) fasta scores: E(): 0.0003, 25.88% id in 170 aa, and has region in common with Enterococcus faecium protein VanZ SWALL:VANZ_ENTFC (SWALL:Q06242) (161 aa) fasta scores: E(): 0.19, 29.16% id in 96 aa.
      
 0.733
folE
Similar to Bacillus subtilis GTP cyclohydrolase I FolE or MtrA SW:GCH1_BACSU (P19465) (190 aa) fasta scores: E(): 4.8e-42, 59.67% id in 186 aa, and to Mycobacterium tuberculosis GTP cyclohydrolase I FolE or GchA or Rv3609c or MT3713 or MTCY07H7B.13 SW:GCH1_MYCTU (O06273) (202 aa) fasta scores: E(): 9.6e-54, 76.63% id in 184 aa.
       0.670
ftsH
Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
       0.670
lysU
Putative lysyl-tRNA synthetase; Similar to Escherichia coli heat inducible lysyl-tRNA synthetase LysU SW:SYK2_ECOLI (P14825) (504 aa) fasta scores: E(): 4.5e-73, 40.8% id in 522 aa, and to Mycobacterium tuberculosis lysyl-tRNA synthetase 1 Rv3598c SW:SYK1_MYCTU (O06284) (505 aa) fasta scores: E(): 3.9e-118, 61.87% id in 522 aa; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
  
 0.569
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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