Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
hptSimilar to Vibrio harveyi hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_VIBHA (P18134) (176 aa) fasta scores: E(): 5.3e-28, 48.21% id in 168 aa, and to Mycobacterium leprae hypoxanthine-guanine phosphoribosyltransferase ML0214 SW:HPRT_MYCLE (O69537) (203 aa) fasta scores: E(): 3.2e-40, 55.31% id in 188 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (187 aa)    
Predicted Functional Partners:
guaA
GMP synthase [glutamine-hydrolysing]; Catalyzes the synthesis of GMP from XMP.
  
 
 0.966
tilS
Conserved hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family.
 
  
 0.963
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
    
 0.952
purA
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.942
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 
 0.935
purH
Similar to Mycobacterium tuberculosis bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3); IMP cyclohydorlase (EC 3.5.4.10)] or Rv0957 or MT0984 or MTCY10D7.17c SW:PUR9_MYCTU (P71553) (523 aa) fasta scores: E(): 1e-137, 68.06% id in 526 aa, and to Escherichia coli bifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3); IMP cyclohydrolase (EC 3.5.4.10)] PurH or B4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1e-58, 45.25% id in 537 aa.
  
 
 0.926
ftsH
Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
  
  
 0.920
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
 
  
 0.912
DIP1594
Conserved hypothetical protein; Similar to Corynebacterium glutamicum hypothetical 26.0 kDa protein in FtsZ 3'region SW:YFTZ_CORGL (P94338) (246 aa) fasta scores: E(): 6.5e-66, 68.72% id in 243 aa, and to Streptomyces griseus hypothetical 25.3 kDa protein in FtsZ 3'region SW:YFTZ_STRGR (P45496) (246 aa) fasta scores: E(): 7.4e-41, 50% id in 228 aa; Belongs to the multicopper oxidase YfiH/RL5 family.
  
 
  0.912
DIP1285
Conserved hypothetical protein; Similar to Rhizobium loti Mll8746 protein SWALL:Q989X1 (EMBL:AP003008) (280 aa) fasta scores: E(): 3.4e-12, 28.57% id in 210 aa, and to Xylella fastidiosa GMP synthase XF0560 SWALL:Q9PFU7 (EMBL:AE003903) (240 aa) fasta scores: E(): 8.5e-09, 26.97% id in 215 aa.
  
 
 0.911
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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