STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tilSConserved hypothetical protein; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (280 aa)    
Predicted Functional Partners:
hpt
Similar to Vibrio harveyi hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_VIBHA (P18134) (176 aa) fasta scores: E(): 5.3e-28, 48.21% id in 168 aa, and to Mycobacterium leprae hypoxanthine-guanine phosphoribosyltransferase ML0214 SW:HPRT_MYCLE (O69537) (203 aa) fasta scores: E(): 3.2e-40, 55.31% id in 188 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
 0.973
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
     
 0.862
DIP2005
Putative D-Ala D-Ala carboxypeptidase; Similar to Mycobacterium tuberculosis hypothetical 46.8 kDa protein Rv3627c or MT3729 or MTCY15C10.25 SWALL:AAK48090 (EMBL:Z95436) (461 aa) fasta scores: E(): 5.2e-11, 37.04% id in 440 aa, and to Escherichia coli penicillin-binding protein 4 precursor DacB or B3182 SWALL:PBP4_ECOLI (SWALL:P24228) (477 aa) fasta scores: E(): 4.4e-05, 26.55% id in 433 aa.
     
 0.850
DIP0032
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 6.6 kDa protein SC6E10.02 TR:Q9S2N5 (EMBL:AL109661) (66 aa) fasta scores: E(): 1.1e-06, 36.36% id in 66 aa.
  
   0.706
DIP2009
Putative peptide synthase; N-terminal region similar to C-terminal region of Streptomyces lavendulae peptide synthetase SWALL:AAK81825 (EMBL:AF386507) (1531 aa) fasta scores: E(): 1.3e-38, 34.02% id in 814 aa, similar in its full length to Agrobacterium tumefaciens StrC58 AGR_l_3476p SWALL:AAK90311 (EMBL:AE008376) (1344 aa) fasta scores: E(): 6.2e-36, 32.96% id in 1338 aa, and N-terminal region similar to the full length of Amycolatopsis orientalis PCZA361.18 SWALL:O52803 (EMBL:AJ223998) (580 aa) fasta scores: E(): 1.3e-33, 38.2% id in 589 aa. C-terminal region presents low similarity [...]
  
 
 0.698
lysS
Appears to be a gene fusion. N-terminal region similar to Streptomyces coelicolor putative integral membrane protein SC3C8.03c TR:O69916 (EMBL:AL023861) (589 aa) fasta scores: E(): 4.3e-57, 37.26% id in 577 aa. C-terminal region similar to Thermus aquaticus lysyl-tRNA synthetase LysS SW:SYK_THETH (P41255) (492 aa) fasta scores: E(): 9.8e-57, 40.8% id in 446 aa; Belongs to the class-II aminoacyl-tRNA synthetase family.
   
 
 0.680
ftsH
Cell division protein; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.
     
 0.673
ppa
Inorganic pyrophosphatase; Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.
       0.673
folE
Similar to Bacillus subtilis GTP cyclohydrolase I FolE or MtrA SW:GCH1_BACSU (P19465) (190 aa) fasta scores: E(): 4.8e-42, 59.67% id in 186 aa, and to Mycobacterium tuberculosis GTP cyclohydrolase I FolE or GchA or Rv3609c or MT3713 or MTCY07H7B.13 SW:GCH1_MYCTU (O06273) (202 aa) fasta scores: E(): 9.6e-54, 76.63% id in 184 aa.
     
 0.649
metG
methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.
     
 0.612
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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