STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
uvrA2Similar to Pseudomonas lemoignei putative excinuclease ABC subunit A UvrA SWALL:UVRA_PSELE (SWALL:P52087) (689 aa) fasta scores: E(): 1.1e-73, 60.02% id in 703 aa, and to Micrococcus luteus excinuclease ABC subunit A UvrA SWALL:UVRA_MICLU (SWALL:P13567) (992 aa) fasta scores: E(): 8.7e-50, 38.63% id in 1012 aa, and to Streptomyces coelicolor excinuclease ABC subunit A Uvra or SCC54.18c SWALL:UVRA_STRCO (SWALL:Q9Z507) (1014 aa) fasta scores: E(): 2.8e-49, 39.67% id in 993 aa. (863 aa)    
Predicted Functional Partners:
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
 
 
 0.989
uvrA
Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
  
  
 
0.910
uvrC
Putative excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
 
 
 0.829
mfd
Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
   
 
 0.789
pcrA
Similar to Mycobacterium leprae ATP-dependent DNA helicase PcrA or UvrD or ML0153 SW:PCRA_MYCLE (Q9CD72) (778 aa) fasta scores: E(): 5.7e-165, 59.08% id in 804 aa, and to Bacillus subtilis ATP-dependent DNA helicase PcrA SW:PCRA_BACSU (O34580) (739 aa) fasta scores: E(): 4.1e-80, 42.76% id in 802 aa.
 
 
 0.586
uvrD
Putative DNA helicase II; Similar to Mycobacterium tuberculosis probable DNA helicase II homolog UvrD or Rv3198c or MT3291 or MTV014.42c SW:UVRD_MYCTU (O53344) (700 aa) fasta scores: E(): 2.7e-133, 58.92% id in 689 aa, and to Escherichia coli DNA helicase II UvrD or MutU or PdeB or Rad or RecL or B3813 SW:UVRD_ECOLI (P03018) (720 aa) fasta scores: E(): 7.8e-37, 32.16% id in 656 aa.
 
 
 0.574
recA
Recombinase A; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
  
 0.488
recN
DNA repair protein; May be involved in recombinational repair of damaged DNA.
 
  
 0.485
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
     
 0.436
DIP2032
Putative protease; Similar to Pseudomonas aeruginosa probable protease PA4171 SWALL:Q9HWL0 (EMBL:AE004833) (187 aa) fasta scores: E(): 3.2e-25, 50.28% id in 175 aa, and to Pyrococcus furiosus protease I PfpI or PF1719 SWALL:PFPI_PYRFU (SWALL:Q51732) (166 aa) fasta scores: E(): 1.8e-19, 40.58% id in 170 aa.
       0.430
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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