STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2042Conserved hypothetical protein; ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity; Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. (359 aa)    
Predicted Functional Partners:
DIP1798
Putative aminopeptidase; Similar to Streptomyces lividans aminopeptidase N PepN SW:AMPN_STRLI (Q11010) (857 aa) fasta scores: E(): 1.2e-88, 45.27% id in 888 aa, and to Mycobacterium tuberculosis aminopeptidase Rv2467 TR:O53194 (EMBL:AL021246) (861 aa) fasta scores: E(): 1.9e-132, 51.97% id in 885 aa. CDS appears to be extended at the N-terminus in comparison to orthologues. Possible alternative translational start site, although current start has better RBS and extented region contains Pfam hit.
     
 0.903
pepA
Putative aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides.
     
  0.900
DIP2043
Putative secreted protein; No significant database matches.
       0.842
DIP2044
Conserved hypothetical protein; Similar to Streptomyces coelicolor hypothetical 9.6 kDa protein SCD95A.20 SWALL:Q9KXV4 (EMBL:AL357432) (84 aa) fasta scores: E(): 1e-08, 54.09% id in 61 aa, and to Mycobacterium tuberculosis hypothetical 11.7 kDa protein Rv0430 or MT0445 or MTCY22G10.27 SWALL:P96276 (EMBL:Z84724) (102 aa) fasta scores: E(): 2.2e-07, 48.38% id in 62 aa.
       0.842
gdh
Similar to Corynebacterium glutamicum NADP-specific glutamate dehydrogenase Gdh SW:DHE4_CORGL (P31026) (447 aa) fasta scores: E(): 6.8e-138, 77.84% id in 465 aa, and to Escherichia coli NADP-specific glutamate dehydrogenase GdhA or B1761 SW:DHE4_ECOLI (P00370) (447 aa) fasta scores: E(): 3.6e-97, 59.55% id in 445 aa; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
     
  0.800
glnA1
Glutamine synthetase I; Similar to Corynebacterium glutamicum glutamine synthetase I GlnA TR:O32354 (EMBL:Y13221) (477 aa) fasta scores: E(): 6.8e-157, 79.49% id in 478 aa, and to Streptomyces coelicolor glutamine synthetase GlnA or SC3H12.06 SW:GLNA_STRCO (P15106) (469 aa) fasta scores: E(): 3.6e-128, 66.31% id in 475 aa. Also similar to DIP1671, glnA2 (456 aa); fasta scores: E(): 5e-31, 32.353% identity in 476 aa overlap.
     
  0.800
glnA2
Glutamine synthetase II; Similar to Corynebacterium glutamicum glutamine synthetase II GlnA2 TR:Q9AEL4 (EMBL:AJ310086) (427 aa) fasta scores: E(): 4.4e-141, 78.4% id in 426 aa, and to Bacillus subtilis glutamine synthetase GlnA SW:GLNA_BACSU (P12425) (443 aa) fasta scores: E(): 1.3e-69, 44.62% id in 437 aa. Note: Also similar to DIP1644 (478 aa); fasta scores: E(): 9.9e-32; 32.353% identity in 476 aa overlap.
     
  0.800
aecD
Beta C-S lyase; Similar to Corynebacterium glutamicum beta C-S lyase AecD TR:Q46061 (EMBL:M89931) (325 aa) fasta scores: E(): 3e-66, 53.93% id in 330 aa.
     
  0.800
DIP1890
Putative cysteine synthase; Similar to the C-terminal region of Arabidopsis thaliana cysteine synthase, mitochondrial precursor ACS 1 SW:CYSM_ARATH (Q43725) (424 aa) fasta scores: E(): 1.5e-58, 53.39% id in 309 aa, and to the full length Neisseria meningitidis (serogroup A) putative cysteine synthase NMA0974 TR:Q9JQL6 (EMBL:AL162754) (310 aa) fasta scores: E(): 5.6e-65, 59.09% id in 308 aa.
     
  0.800
def
Peptide deformylase; Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.
       0.715
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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