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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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[Homology]
Score
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)    
Predicted Functional Partners:
purB
Similar to Homo sapiens adenylosuccinate lyase AdsL SW:PUR8_HUMAN (P30566) (484 aa) fasta scores: E(): 3.3e-39, 33.19% id in 470 aa, and to Corynebacterium ammoniagenes adenylosuccino lyase PurB TR:Q9RHX3 (EMBL:AB003161) (479 aa) fasta scores: E(): 4.4e-148, 82.91% id in 480 aa.
 
 0.996
purH
Similar to Mycobacterium tuberculosis bifunctional purine biosynthesis protein PurH [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3); IMP cyclohydorlase (EC 3.5.4.10)] or Rv0957 or MT0984 or MTCY10D7.17c SW:PUR9_MYCTU (P71553) (523 aa) fasta scores: E(): 1e-137, 68.06% id in 526 aa, and to Escherichia coli bifunctional purine biosynthesis protein [includes: phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3); IMP cyclohydrolase (EC 3.5.4.10)] PurH or B4006 SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 1e-58, 45.25% id in 537 aa.
  
 0.987
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
 
 
 0.985
purC
Putative phosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to Saccharomyces cerevisiae phosphoribosylamidoimidazole-succinocarboxamide synthase ADE1 SW:PUR7_YEAST (P27616) (306 aa) fasta scores: E(): 7.6e-34, 44.06% id in 295 aa, and to Corynebacterium ammoniagenes 5'-phosphoribosyl-4-N-succinocarboxamide-5-amino imidazole synthetase PurC TR:Q9RHX2 (EMBL:AB003161) (295 aa) fasta scores: E(): 2e-89, 75.84% id in 294 aa.
  
 
 0.972
DIP0581
Conserved hypothetical protein; Similar to Corynebacterium ammoniagenes GuaB, ORF genes for IMP dehydrogenase, hypothetical protein TR:Q9RHY9 (EMBL:AB003154) (376 aa) fasta scores: E(): 3.5e-63, 67.18% id in 387 aa, and C-terminal region similar to Escherichia coli inosine-5'-monophosphate dehydrogenase GuaB or GuaR or B2508 or Z3772 or ECS3370 SW:IMDH_ECOLI (P06981) (488 aa) fasta scores: E(): 0.00061, 31.49% id in 181 aa.
  
 
 0.965
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
 
 0.963
DIP2130
Full length similarity to Streptococcus pneumoniae phosphoribosylformylglycinamidine synthase, putative SP0045 TR:AAK74234 (EMBL:AE007322) (1241 aa) fasta scores: E(): 7.8e-167, 47.73% id in 1259 aa. Second two thirds similar to many others e.g. Mycobacterium tuberculosis phosphoribosylformylglycinamidine synthase II PurL or Rv0803 or MT0823 or MTCY07H7A.06c SW:PURL_MYCTU (P54876) (754 aa) fasta scores: E(): 8.3e-22, 26.35% id in 740 aa.
  
  
 0.955
hpt
Similar to Vibrio harveyi hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_VIBHA (P18134) (176 aa) fasta scores: E(): 5.3e-28, 48.21% id in 168 aa, and to Mycobacterium leprae hypoxanthine-guanine phosphoribosyltransferase ML0214 SW:HPRT_MYCLE (O69537) (203 aa) fasta scores: E(): 3.2e-40, 55.31% id in 188 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.942
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
 
 0.940
pyrB
Similar to Mycobacterium leprae aspartate carbamoyltransferase PyrB or ML0532 SWALL:PYRB_MYCLE (SWALL:Q9CCR5) (321 aa) fasta scores: E(): 5.4e-79, 66.98% id in 312 aa, and to Bacillus subtilis aspartate carbamoyltransferase PyrB SWALL:PYRB_BACSU (SWALL:P05654) (304 aa) fasta scores: E(): 3.2e-32, 39.53% id in 301 aa; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
  
 
 0.927
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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