STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2096Putative RNA methylase family protein; Similar to although shoter in its N-terminal region than Mycobacterium tuberculosis CDC1551 SpoU rRNA methylase family protein MT0393 SWALL:AAK44615 (EMBL:AE006944) (183 aa) fasta scores: E(): 6.2e-51, 74.41% id in 172 aa, and to Escherichia coli tRNA TrmH or SpoU or B3651 or Z5077 or ECS4526 SWALL:TRMH_ECOLI (SWALL:P19396) (229 aa) fasta scores: E(): 4.6e-07, 28.94% id in 152 aa. (172 aa)    
Predicted Functional Partners:
DIP2095
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis CDC1551 fructose-bisphosphate aldolase family protein MT0381 SWALL:AAK44602 (EMBL:AE006943) (376 aa) fasta scores: E(): 7.2e-55, 43.61% id in 376 aa, and to Corynebacterium glutamicum hypothetical protein in fda 5' region SWALL:Q99336 (EMBL:X17313) (304 aa) fasta scores: E(): 1.6e-37, 60.55% id in 289 aa.
       0.835
DIP1017
Putative NUDIX-family hydrolase; Similar to Staphylococcus aureus (strain N315) SA2278 or SAV2490 TR:BAB58652 (EMBL:AP003137) (130 aa) fasta scores: E(): 1e-24, 56.91% id in 123 aa, and to Escherichia coli CTP pyrophosphohydrolase NudG or B1759 SW:NUDG_ECOLI (P77788) (135 aa) fasta scores: E(): 3.3e-13, 41.4% id in 128 aa.
 
 
    0.719
fba
Fructose-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis; Belongs to the class II fructose-bisphosphate aldolase family.
 
     0.708
pyrE
Phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
    0.664
rplQ
Similar to Mycobacterium leprae 50S ribosomal protein L17 RplQ or ML1956 or MLCB1222.26c SW:RL17_MYCLE (Q9X797) (170 aa) fasta scores: E(): 3.1e-26, 58.86% id in 158 aa.
  
   0.627
rsfS
Conserved hypothetical protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.
   
   0.624
rplU
50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
   
   0.623
rplO
50s ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
   
   0.620
rplM
50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
   0.620
rplK
50S ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.
   
   0.619
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.