STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
clpB2Putative heat shock protein (partial); Similar to Corynebacterium glutamicum ClpB protein SWALL:CLPB_CORGL (SWALL:P53532) (852 aa) fasta scores: E(): 0.027, 44.44% id in 99 aa, and to Mycobacterium leprae heat shock protein ClpB or ML2490 SWALL:Q9CB26 (EMBL:AL583925) (848 aa) fasta scores: E(): 0.66, 35.41% id in 96 aa. Note: Similar also to the C-terminal part of DIP2104 (849 aa) E(): 7.2e-08; 53.465% identity in 101 aa overlap. (66 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.955
clpP2
ATP-dependent Clp protease proteolytic subunit 2; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
 
 0.878
grpE
Chaperone protein cofactor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...]
  
 
 0.847
clpP1
ATP-dependent Clp protease proteolytic subunit 1; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
   
 
 0.795
clpS
Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
  
 
 0.788
DIP0485
Putative ABC transport system integral membrane protein; Similar to Bacillus halodurans BH3121 protein TR:Q9K885 (EMBL:AP001517) (398 aa) fasta scores: E(): 4e-20, 33.33% id in 438 aa.
   
  
 0.756
DIP0483
Putative secreted protein; C-terminal region presents los similarity to Streptococcus pneumoniae hypothetical protein SP0785 TR:AAK74922 (EMBL:AE007385) (399 aa) fasta scores: E(): 4e-08, 28.25% id in 315 aa.
   
  
 0.752
DIP0484
Putative ABC transport system ATP-binding protein; Similar to Bacillus subtilis YknY protein TR:O31711 (EMBL:Z99111) (230 aa) fasta scores: E(): 3.2e-43, 57.01% id in 221 aa.
  
  
 0.746
DIP1576
Putative RNA-binding heat shock protein; Similar to Rhizobium loti MLR3853 protein TR:Q98FB3 (EMBL:AP003002) (131 aa) fasta scores: E(): 2.9e-09, 42.01% id in 119 aa, and to Escherichia coli heat shock protein 15 HslR or B3400 or Z4754 or ECS4242 SW:HSLR_ECOLI (P45802) (133 aa) fasta scores: E(): 2.7e-06, 32.54% id in 126 aa.
   
  
 0.746
DIP1886
Similar to Streptomyces coelicolor putative ABC transport system ATP-binding protein SCE41.20c TR:Q9F2N9 (EMBL:AL442120) (262 aa) fasta scores: E(): 9.4e-54, 63.9% id in 241 aa, and to Streptomyces coelicolor putative ABC transporter ATP-binding protein SCE25.30 TR:Q9KZ60 (EMBL:AL354048) (256 aa) fasta scores: E(): 4.6e-53, 67.37% id in 236 aa.
  
  
 0.746
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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