STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2103Putative membrane protein; No significant database matches. (50 aa)    
Predicted Functional Partners:
DIP2102
Putative membrane protein; No significant database matches.
       0.773
clpB2
Putative heat shock protein (partial); Similar to Corynebacterium glutamicum ClpB protein SWALL:CLPB_CORGL (SWALL:P53532) (852 aa) fasta scores: E(): 0.027, 44.44% id in 99 aa, and to Mycobacterium leprae heat shock protein ClpB or ML2490 SWALL:Q9CB26 (EMBL:AL583925) (848 aa) fasta scores: E(): 0.66, 35.41% id in 96 aa. Note: Similar also to the C-terminal part of DIP2104 (849 aa) E(): 7.2e-08; 53.465% identity in 101 aa overlap.
       0.487
clpB
Putative ATP-dependent protease regulatory subunit, ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belong [...]
       0.481
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.