STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2105Putative exported protein; Similar to the N-terminal portion of many from actinomycetes eg. Streptomyces coelicolor putative secreted protein SCE41.06c TR:Q9F2Q2 (EMBL:AL442120) (244 aa) fasta scores: E(): 7.5e-21, 65.74% id in 108 aa. Also full length similarity to others from actinomycetes eg. Streptomyces coelicolor putative membrane protein SC5C11.15 TR:Q9L157 (EMBL:AL158060) (121 aa) fasta scores: E(): 1.9e-14, 50.49% id in 101 aa. (109 aa)    
Predicted Functional Partners:
DIP2375
Putative hydrolase; Similar to Mycobacterium tuberculosis putative hydrolase CwlM or Rv3915 or MTV028.06 TR:O53593 (EMBL:AL021426) (406 aa) fasta scores: E(): 5.4e-78, 52.38% id in 399 aa, and to Bacillus subtilis N-acetylmuramoyl-L-alanine amidase CwlB precursor or LytC SW:CWLB_BACSU (Q02114) (496 aa) fasta scores: E(): 2.8e-07, 25.62% id in 199 aa.
 
   
 0.642
beta371
Immunity-specific protein Beta371; Almost identical to previously sequenced Corynephage beta immunity-specific protein Beta371 beta371 TR:Q37922 (EMBL:L04258) (371 aa) fasta scores: E(): 9.9e-126, 89.75% id in 371 aa.
   
 
 0.613
DIP2106
Similar to Streptomyces coelicolor putative ABC transport system ATP-binding protein SCD10.29c TR:Q9K3U8 (EMBL:AL359988) (263 aa) fasta scores: E(): 8.8e-37, 49.6% id in 252 aa, and to Caulobacter crescentus ABC transporter, ATP-binding protein CC0838 TR:Q9A9X3 (EMBL:AE005760) (250 aa) fasta scores: E(): 2.6e-27, 42.25% id in 239 aa.
       0.534
DIP2107
Similar to Streptomyces coelicolor putative integral membrane transport protein SCD10.28c TR:Q9K3U9 (EMBL:AL359988) (550 aa) fasta scores: E(): 6.2e-18, 25.27% id in 542 aa. Lies alongside a putative ABC transporter ATP-binding subunit.
       0.534
DIP1797
Similar to Mycobacterium tuberculosis hypothetical protein Rv2466c TR:O53193 (EMBL:AL021246) (207 aa) fasta scores: E(): 2.5e-43, 57.63% id in 203 aa, and to Mycobacterium leprae hypothetical protein ML1485 TR:Q9CBY0 (EMBL:AL583922) (207 aa) fasta scores: E(): 1.7e-40, 55.94% id in 202 aa.
  
     0.458
clpB
Putative ATP-dependent protease regulatory subunit, ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belong [...]
  
    0.455
repA
Putative IS element transposase (pseudogene); Pseudogene. Similar to although shorter in its N-terminal region than Shigella flexneri putative transposase for IS110 S0128 SWALL:Q9AFS5 (EMBL:AF348706) (398 aa) fasta scores: E(): 1.6e-18, 40.55% id in 254 aa, and similar to Streptomyces coelicolor putative IS element transposase SC3C8.17 SWALL:O69929 (EMBL:AL023861) (230 aa) fasta scores: E(): 7.9e-18, 45.61% id in 171 aa. Presents multiple frameshifts at residues 84, 125, 130, 145, 150 and 180.
  
  
 0.425
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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