STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
adhASimilar to Rhizobium meliloti alcohol dehydrogenase AdhA or RA0704 or SMA1296 SWALL:ADHA_RHIME (SWALL:O31186) (340 aa) fasta scores: E(): 1.4e-71, 55.09% id in 334 aa, and to Pseudomonas aeruginosa alcohol dehydrogenase AdhA or PA5427 SWALL:Q9HTD9 (EMBL:AE004955) (342 aa) fasta scores: E(): 1.5e-79, 58.99% id in 339 aa. (346 aa)    
Predicted Functional Partners:
DIP2115
Putative aldehyde dehydrogenase; Similar to many eg. Acinetobacter spM-1. aldehyde dehydrogenase 1 Ald1 TR:Q9FDS1 (EMBL:AB042203) (503 aa) fasta scores: E(): 2.5e-143, 69.18% id in 503 aa, and to Alcaligenes eutrophus acetaldehyde dehydrogenase II AcoD SW:DHA2_ALCEU (P46368) (506 aa) fasta scores: E(): 1.8e-135, 66.39% id in 497 aa.
 
 
 0.958
pta
Phosphate acetyltransferase; Highly similar in its C-terminal region to Corynebacterium glutamicum phosphate acetyltransferase Pta SWALL:PTA_CORGL (SWALL:P77844) (329 aa) fasta scores: E(): 6.9e-94, 78.22% id in 326 aa, similar to the C-terminal region of Mycobacterium tuberculosis phosphate acetyltransferase Pta or Rv0408 or MT0421 or MTCY22G10.04 SWALL:PTA_MYCTU (SWALL:P96254) (690 aa) fasta scores: E(): 4.8e-68, 48.67% id in 452 aa, and similar to the C-terminal region of Escherichia coli phosphate acetyltransferase Pta or B2297 SWALL:PTA_ECOLI (SWALL:P39184) (713 aa) fasta scores: [...]
   
  
 0.768
DIP2135
Similar to Neisseria meningitidis putative zinc-binding alcohol dehydrogenase NMA0808 TR:Q9JVJ8 (EMBL:AL162754) (354 aa) fasta scores: E(): 1.1e-85, 64.62% id in 359 aa, and to Bacillus cereus acetylacetoin reductase AacR TR:BAB60856 (EMBL:AB063194) (349 aa) fasta scores: E(): 5.6e-47, 42.25% id in 355 aa, and to Pseudomonas putida 2,3-butanediol dehydrogenase Adh TR:Q59696 (EMBL:L35343) (362 aa) fasta scores: E(): 6.6e-40, 37.63% id in 364 aa.
 
 
 0.595
ilvD
Similar to Streptomyces coelicolor dihydroxy-acid dehydratase IlvD or SCE7.12c SW:ILVD_STRCO (O69198) (617 aa) fasta scores: E(): 1.7e-161, 67.9% id in 617 aa, and to Escherichia coli dihydroxy-acid dehydratase IlvD or B3771 SW:ILVD_ECOLI (P05791) (616 aa) fasta scores: E(): 1.4e-155, 67.37% id in 613 aa; Belongs to the IlvD/Edd family.
   
 
 0.575
fas
Putative fatty acid synthase; Similar to the N-terminal region of Corynebacterium ammoniagenes fatty acid synthase Fas TR:Q04846 (EMBL:X64795) (3104 aa) fasta scores: E(): 0, 61.33% id in 3018 aa, and to the full length of Mycobacterium tuberculosis fatty acid synthase Rv2524c TR:AAK46907 (EMBL:Z83863) (3069 aa) fasta scores: E(): 1e-197, 51.37% id in 3083 aa, and of Corynebacterium glutamicum 3-oxoacyl-(acyl-carrier-protein) synthase CGL2495 SWALL:Q8NMS0 (EMBL:AP005281) (2993 aa) fasta scores: E(): 0, 67.35% id in 3008 aa.
  
 
 0.539
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
      
 0.483
gltA
Citrate synthase; Similar to Corynebacterium glutamicum citrate synthase GltA SW:CISY_CORGL (P42457) (437 aa) fasta scores: E(): 2.5e-151, 87.52% id in 433 aa.
   
  
 0.437
rpmE
Similar to Streptomyces coelicolor 50S ribosomal protein L31 type B-2 RpmE3 or SCE9.34c TR:Q9X8K6 (EMBL:AL049841) (84 aa) fasta scores: E(): 1.4e-18, 60.75% id in 79 aa.
   
  
 0.430
DIP0163
Hypothetical protein; No significant database matches.
   
  
 0.401
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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