Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dcdDeoxycytidine triphosphate deaminase; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. (187 aa)    
Predicted Functional Partners:
dut
Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family.
    
 0.941
ndk
Putative nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
  
 
 0.920
DIP0465
Conserved hypothetical protein; Similar to C-terminal region of Alcaligenes eutrophus NrdD protein TR:Q9ZER4 (EMBL:AJ012479) (676 aa) fasta scores: E(): 1.4e-167, 71.81% id in 550 aa.
    
 0.901
DIP2141
Similar to Streptomyces coelicolor putative UDP-glucose 6-dehydrogenase SCBAC19G2.07 TR:CAC44517 (EMBL:AL596138) (447 aa) fasta scores: E(): 2.8e-33, 40.75% id in 422 aa, and to Pseudomonas aeruginosa UDP-glucose 6-dehydrogenase Udg or pa2022 SW:UDG_PSEAE (O86422) (453 aa) fasta scores: E(): 1.9e-26, 39.66% id in 358 aa, and to Rhizobium meliloti UDP-glucose 6-dehydrogenase Rkpk or r01082 or smc02641 SW:UDG_RHIME (O54068) (437 aa) fasta scores: E(): 8.9e-26, 37.71% id in 411 aa, and to Escherichia coli UDP-glucose 6-dehydrogenase KfiD SW:UDG5_ECOLI (Q47329) (392 aa) fasta scores: E(): [...]
       0.836
DIP0361
Putative bifunctional protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose.
   
   0.759
DIP2139
Hypothetical protein; No significant database matches.
       0.701
DIP2140
Putative integral membrane protein; Weakly similar to Lactococcus lactis unknown protein YldA or ll1118 TR:Q9CGH8 (EMBL:AE006344) (209 aa) fasta scores: E(): 0.092, 24% id in 175 aa.
       0.701
parB
Similar to Mycobacterium tuberculosis probable chromosome partitioning protein ParB or Rv3917c or MT4036 or MTV028.08c SW:PARB_MYCTU (O53595) (344 aa) fasta scores: E(): 7.4e-47, 54.93% id in 375 aa, and to Streptomyces coelicolor putative chromosome partitioning protein ParB TR:Q9RFM2 (EMBL:AF187159) (368 aa) fasta scores: E(): 3.2e-43, 47.69% id in 369 aa; Belongs to the ParB family.
      
 0.639
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
      
 0.536
guaA
GMP synthase [glutamine-hydrolysing]; Catalyzes the synthesis of GMP from XMP.
  
  
 0.410
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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