STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2158Pseudogene. Similar to C-terminus of Bacteriophage SP02 DNA polymerase L SWALL:DPOL_BPSP2 (SWALL:P06225) (648 aa) fasta scores: E(): 1.3e-34, 50.61% id in 245 aa, and to Xylella fastidiosa phage-related DNA polymerase XF0683 SWALL:Q9PFH5 (EMBL:AE003912) (726 aa) fasta scores: E(): 6e-19, 32.49% id in 277 aa. Presents a frameshift at residue 46. (584 aa)    
Predicted Functional Partners:
DIP2161
Nonribosomal peptide synthase; Similar to Stigmatella aurantiaca myxothiazol synthase MtaC TR:Q9RFK9 (EMBL:AF188287) (1290 aa) fasta scores: E(): 1.7e-86, 35.694% id in 1073 aa, and to Polyangium cellulosum epothilone biosynthase EpoB TR:Q9KIZ9 (EMBL:AF217189) (1410 aa) fasta scores: E(): 1.8e-81, 35.385% id in 975 aa, and to Pseudomonas aeruginosa pyochelin synthetase PchF or PA4225 TR:Q9HWG4 (EMBL:AE004839) (1809 aa) fasta scores: E(): 1.9e-81, 37.017% id in 932 aa.
 
 
 0.905
DIP2159
ABC transport protein; Similar to Yersinia enterocolitica lipoprotein inner membrane ABC-transporter, Irp6 TR:Q9X9I5 (EMBL:AJ132668) (600 aa) fasta scores: E(): 2.5e-43, 34.286% id in 560 aa, and to Streptomyces natalensis PimB protein TR:Q9EW97 (EMBL:AJ278573) (626 aa) fasta scores: E(): 3e-37, 32.519% id in 532 aa.
 
    
0.879
DIP2160
Modular polyketide synthase; Similar to Streptomyces verticillus polyketide synthase BlmVIII (bleomycin biosynthesis) TR:Q9FB25 (EMBL:AF210249) (1841 aa) fasta scores: E(): 1.3e-72, 27.240% id in 1931 aa, and to Streptomyces noursei nystatin biosynthesis polyketide synthase Nys TR:Q9L4W3 (EMBL:AF263912) (11096 aa) fasta scores: E(): 4e-71, 33.107% id in 882 aa, and to Amycolatopsis mediterranei rifamycin polyketide synthase TR:Q9F847 (EMBL:AF262754) (1265 aa) fasta scores: E(): 7.7e-61, 31.042% id in 902 aa.
  
 0.829
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.717
DIP0754
Putative lantibiotic ABC-transport system membrane protein; Similar to Staphylococcus aureus transporter TR:Q9S4D0 (EMBL:AF147744) (720 aa) fasta scores: E(): 2.4e-57, 29.986% id in 707 aa, and to Lactococcus lactis cytolysin B transport protein TR:O87239 (EMBL:AE001272) (708 aa) fasta scores: E(): 7.1e-55, 28.571% id in 714 aa.
 
 
  
0.696
trpE
Similar to Corynebacterium glutamicum anthranilate synthase component I TrpE SW:TRPE_CORGL (P06557) (518 aa) fasta scores: E(): 5.7e-128, 65.44% id in 518 aa, and to Escherichia coli anthranilate synthase component I trpE or b1264 SW:TRPE_ECOLI (P00895) (520 aa) fasta scores: E(): 6.3e-66, 47.44% id in 508 aa.
   
  
 0.695
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
  
   0.600
DIP0321
Similar to Streptomyces coelicolor ABC transporter ATP-binding protein SC4A2.02c TR:O86658 (EMBL:AL031182) (229 aa) fasta scores: E(): 6.7e-12, 39.3% id in 201 aa.
  
     0.566
dnaJ2
Chaperone protein 2; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]
  
 
   0.557
dnaJ1
Chaperone protein cofactor 1; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between D [...]
  
 
   0.554
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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