STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2189Putative polyketide synthase; Similar to Mycobacterium tuberculosis polyketide synthase PKS13 or Rv3800c or MTV026.05c TR:O53579 (EMBL:AL022076) (1733 aa) fasta scores: E(): 5.4e-109, 44.5% id in 1719 aa, and to Polyangium cellulosum soraphen polyketide synthase A SorA TR:Q9ADL6 (EMBL:U24241) (6315 aa) fasta scores: E(): 6.2e-101, 35.96% id in 1090 aa. (1586 aa)    
Predicted Functional Partners:
fas
Putative fatty acid synthase; Similar to the N-terminal region of Corynebacterium ammoniagenes fatty acid synthase Fas TR:Q04846 (EMBL:X64795) (3104 aa) fasta scores: E(): 0, 61.33% id in 3018 aa, and to the full length of Mycobacterium tuberculosis fatty acid synthase Rv2524c TR:AAK46907 (EMBL:Z83863) (3069 aa) fasta scores: E(): 1e-197, 51.37% id in 3083 aa, and of Corynebacterium glutamicum 3-oxoacyl-(acyl-carrier-protein) synthase CGL2495 SWALL:Q8NMS0 (EMBL:AP005281) (2993 aa) fasta scores: E(): 0, 67.35% id in 3008 aa.
 
0.999
DIP2161
Nonribosomal peptide synthase; Similar to Stigmatella aurantiaca myxothiazol synthase MtaC TR:Q9RFK9 (EMBL:AF188287) (1290 aa) fasta scores: E(): 1.7e-86, 35.694% id in 1073 aa, and to Polyangium cellulosum epothilone biosynthase EpoB TR:Q9KIZ9 (EMBL:AF217189) (1410 aa) fasta scores: E(): 1.8e-81, 35.385% id in 975 aa, and to Pseudomonas aeruginosa pyochelin synthetase PchF or PA4225 TR:Q9HWG4 (EMBL:AE004839) (1809 aa) fasta scores: E(): 1.9e-81, 37.017% id in 932 aa.
 
 0.999
DIP2009
Putative peptide synthase; N-terminal region similar to C-terminal region of Streptomyces lavendulae peptide synthetase SWALL:AAK81825 (EMBL:AF386507) (1531 aa) fasta scores: E(): 1.3e-38, 34.02% id in 814 aa, similar in its full length to Agrobacterium tumefaciens StrC58 AGR_l_3476p SWALL:AAK90311 (EMBL:AE008376) (1344 aa) fasta scores: E(): 6.2e-36, 32.96% id in 1338 aa, and N-terminal region similar to the full length of Amycolatopsis orientalis PCZA361.18 SWALL:O52803 (EMBL:AJ223998) (580 aa) fasta scores: E(): 1.3e-33, 38.2% id in 589 aa. C-terminal region presents low similarity [...]
 
 0.998
DIP2190
Similar to Mycobacterium tuberculosis putative polyketide synthase FadD32 or Rv3801c or MT3908 or MTV026.06c TR:O53580 (EMBL:AL022076) (637 aa) fasta scores: E(): 6.4e-78, 41.07% id in 616 aa, and to Myxococcus xanthus saframycin MX1 synthetase B SafB TR:Q50857 (EMBL:U24657) (1770 aa) fasta scores: E(): 7.7e-59, 37.52% id in 557 aa.
 0.998
DIP2160
Modular polyketide synthase; Similar to Streptomyces verticillus polyketide synthase BlmVIII (bleomycin biosynthesis) TR:Q9FB25 (EMBL:AF210249) (1841 aa) fasta scores: E(): 1.3e-72, 27.240% id in 1931 aa, and to Streptomyces noursei nystatin biosynthesis polyketide synthase Nys TR:Q9L4W3 (EMBL:AF263912) (11096 aa) fasta scores: E(): 4e-71, 33.107% id in 882 aa, and to Amycolatopsis mediterranei rifamycin polyketide synthase TR:Q9F847 (EMBL:AF262754) (1265 aa) fasta scores: E(): 7.7e-61, 31.042% id in 902 aa.
 
 
0.996
DIP1802
Similar to Halobacterium sp hypothetical protein VNG1407C TR:Q9HPZ1 (EMBL:AE005058) (132 aa) fasta scores: E(): 2.8e-09, 37.06% id in 116 aa, and to Pseudomonas aeruginosa hypothetical protein PA2801 TR:Q9I042 (EMBL:AE004707) (134 aa) fasta scores: E(): 4e-07, 35.38% id in 130 aa.
 
 
 0.948
hemL
Similar to Streptomyces coelicolor glutamate-1-semialdehyde 2,1-aminomutase HemL or SCD65.12 SW:GSA_STRCO (Q9F2S0) (438 aa) fasta scores: E(): 4e-96, 62.97% id in 424 aa, and to Escherichia coli glutamate-1-semialdehyde 2,1-aminomutase HemL or Gsa or PopC or B0154 SW:GSA_ECOLI (P23893) (426 aa) fasta scores: E(): 1.7e-75, 52.39% id in 418 aa.
    
 0.941
DIP0177
Similar to Streptomyces coelicolor putative quinone oxidoreductase SCGD3.24c TR:Q9XA55 (EMBL:AL096822) (326 aa) fasta scores: E(): 1.4e-57, 53.87% id in 323 aa.
 
 
 0.920
DIP1472
Putative transferase; Similar to Streptomyces coelicolor hypothetical 24.5 kDa protein Sc5A7.23 TR:O88029 (EMBL:AL031107) (226 aa) fasta scores: E(): 6.2e-26, 45.77% id in 201 aa, and to Streptomyces verticillus phosphopantetheinyl transferase PptA TR:Q9F0Q6 (EMBL:AF210311) (246 aa) fasta scores: E(): 1.6e-24, 44.04% id in 193 aa.
 
  
 0.905
pccB
Putative sortase-substrate protein (pseudogene); 1 probable transmembrane helix predicted for DIP2187 by TMHMM2.0.
  
  
 0.894
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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