Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gbsASimilar to Bacillus subtilis betaine aldehyde dehydrogenase GbsA SW:DHAB_BACSU (P71016) (490 aa) fasta scores: E(): 2e-73, 54.63% id in 496 aa, and to Streptomyces coelicolor betaine aldehyde dehydrogenase GbsA TR:Q9K3J2 (EMBL:AL389898) (509 aa) fasta scores: E(): 3.2e-88, 55.75% id in 504 aa. (525 aa)    
Predicted Functional Partners:
betA
Choline dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.
 
 
 0.952
odhA
2-oxoglutarate dehydrogenase, E1 and E2 components; Similar to Corynebacterium glutamicum 2-oxoglutarate dehydrogenase OdhA TR:P96746 (EMBL:D84102) (1257 aa) fasta scores: E(): 0, 77.37% id in 1242 aa, and to Mycobacterium leprae 2-oxoglutarate dehydrogenase, E1 and E2 components OdhA or ML1095 TR:Q9CC97 (EMBL:AL583920) (1260 aa) fasta scores: E(): 0, 59.37% id in 1253 aa. Similar in the N-terminus to Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2) SucB or B0727 or Z0881 or ECS0752 SW:ODO2_ECOLI (P07016) blastp scores: E(): 4 [...]
  
 0.750
DIP2199
Putative conserved integral membrane protein; Similar to Corynebacterium ammoniagenes Orf2 protein TR:Q9RHY7 (EMBL:AB003155) (163 aa) fasta scores: E(): 6.5e-14, 39.21% id in 153 aa, and to Escherichia coli hypothetical protein YbjG or B0841 SW:YBJG_ECOLI (P75806) (198 aa) fasta scores: E(): 1.9e-06, 32.69% id in 156 aa.
       0.645
ectP
Similar to Corynebacterium glutamicum EctP protein (Transport of ectoine, glycine betaine, proline) TR:O86143 (EMBL:AJ001436) (615 aa) fasta scores: E(): 5.2e-181, 73.23% id in 609 aa, and to Bacillus subtilis glycine betaine transporter OpuD SW:OPUD_BACSU (P54417) (512 aa) fasta scores: E(): 2.4e-65, 38.35% id in 511 aa; Belongs to the BCCT transporter (TC 2.A.15) family.
   
  
 0.611
betT
Similar to Escherichia coli high-affinity choline transport protein BetT or B0314 or Z0401 or ECS0360 SW:BETT_ECOLI (P17447) (677 aa) fasta scores: E(): 1.9e-118, 53.14% id in 668 aa, and to Erwinia amylovora high-affinity choline transport protein BetT TR:Q9F806 (EMBL:AF264948) (676 aa) fasta scores: E(): 2.5e-116, 51.98% id in 681 aa; Belongs to the BCCT transporter (TC 2.A.15) family.
  
  
 0.589
fas
Putative fatty acid synthase; Similar to the N-terminal region of Corynebacterium ammoniagenes fatty acid synthase Fas TR:Q04846 (EMBL:X64795) (3104 aa) fasta scores: E(): 0, 61.33% id in 3018 aa, and to the full length of Mycobacterium tuberculosis fatty acid synthase Rv2524c TR:AAK46907 (EMBL:Z83863) (3069 aa) fasta scores: E(): 1e-197, 51.37% id in 3083 aa, and of Corynebacterium glutamicum 3-oxoacyl-(acyl-carrier-protein) synthase CGL2495 SWALL:Q8NMS0 (EMBL:AP005281) (2993 aa) fasta scores: E(): 0, 67.35% id in 3008 aa.
  
 
 0.524
ptsG
Similar to Corynebacterium glutamicum PTS system, glucose-specific IIABC component PtsG SWALL:PTGA_CORGL (SWALL:Q45298) (674 aa) fasta scores: E(): 2.8e-59, 44.91% id in 688 aa, and to Staphylococcus xylosus PTS system, sucrose-specific IIBC component ScrA SWALL:PTSB_STAXY (SWALL:P51184) (480 aa) fasta scores: E(): 8e-26, 27.73% id in 494 aa.
   
  
 0.520
DIP2196
Conserved putative integral membrane protein; Similar to Mycobacterium tuberculosis hypothetical 32.7 kDa protein Rv3806c or MTV026.11c TR:O53583 (EMBL:AL022076) (302 aa) fasta scores: E(): 1e-67, 59.6% id in 302 aa, and to Streptomyces coelicolor putative integral membrane protein SC5G8.12 TR:Q9KZA2 (EMBL:AL353872) (322 aa) fasta scores: E(): 1.7e-49, 44.51% id in 310 aa; Belongs to the UbiA prenyltransferase family.
     
 0.468
DIP2195
Similar to Mycobacterium tuberculosis putative membrane protein Rv3805c or MT3912 or MTV026.10c TR:O53582 (EMBL:AL022076) (627 aa) fasta scores: E(): 4.1e-25, 36.36% id in 594 aa.
       0.466
DIP2197
Putative integral membrane protein; Similar to Mycobacterium tuberculosis hypothetical 17.2 kDa protein Rv3807c or MTV026.12 TR:O53584 (EMBL:AL022076) (165 aa) fasta scores: E(): 7.9e-29, 52.56% id in 156 aa, and to Streptomyces coelicolor putative integral membrane protein SC5G8.11 TR:Q9KZA3 (EMBL:AL353872) (169 aa) fasta scores: E(): 9.1e-17, 46.04% id in 139 aa.
       0.466
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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