STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
serSseryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (419 aa)    
Predicted Functional Partners:
argS
arginyl-tRNA synthetase; Similar to Mycobacterium tuberculosis arginyl-tRNA synthetase ArgS or Rv1292 or MT1331 or MTCY373.12 SW:SYR_MYCTU (Q10609) (550 aa) fasta scores: E(): 4.5e-144, 65.63% id in 550 aa, and to Bacillus subtilis arginyl-tRNA synthetase ArgS SW:SYR_BACSU (P46906) (556 aa) fasta scores: E(): 1.7e-82, 42.75% id in 545 aa.
  
 
 0.798
cysS1
Similar to Escherichia coli cysteinyl-tRNA synthetase CysS or B0526 SW:SYC_ECOLI (P21888) (461 aa) fasta scores: E(): 2.4e-70, 44.11% id in 467 aa, and to Mycobacterium tuberculosis cysteinyl-tRNA synthetase 1 Rv3580c SW:SYC1_MYCTU (P96862) (469 aa) fasta scores: E(): 1.4e-120, 64.57% id in 463 aa; Belongs to the class-I aminoacyl-tRNA synthetase family.
 
 
 0.789
DIP2239
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 28.5 kDa protein Rv3813c or MTCY409.17 TR:O07810 (EMBL:Z97188) (273 aa) fasta scores: E(): 4.2e-35, 41.69% id in 271 aa, and to Streptomyces coelicolor hypothetical 32.5 kDa protein SCD78.17c TR:Q9ZBY2 (EMBL:AL034355) (305 aa) fasta scores: E(): 2.3e-19, 34.29% id in 277 aa.
  
    0.780
ychF
Putative ABC transport system ATP-binding protein; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
  
  
 0.779
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
  
  
 0.771
DIP2238
Putative acyltransferase; Similar to Mycobacterium tuberculosis acyltransferase Rv3816c or MTCY409.14 TR:O07807 (EMBL:Z97188) (259 aa) fasta scores: E(): 2.5e-34, 47.6% id in 250 aa, and to Brassica napus lysophosphatidic acid acyltransferase Act2 TR:Q9LLY4 (EMBL:AF111161) (344 aa) fasta scores: E(): 4.3e-06, 29.05% id in 148 aa.
       0.765
trpS
tryptophanyl-tRNA synthetase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family.
  
 
 0.748
DIP2160
Modular polyketide synthase; Similar to Streptomyces verticillus polyketide synthase BlmVIII (bleomycin biosynthesis) TR:Q9FB25 (EMBL:AF210249) (1841 aa) fasta scores: E(): 1.3e-72, 27.240% id in 1931 aa, and to Streptomyces noursei nystatin biosynthesis polyketide synthase Nys TR:Q9L4W3 (EMBL:AF263912) (11096 aa) fasta scores: E(): 4e-71, 33.107% id in 882 aa, and to Amycolatopsis mediterranei rifamycin polyketide synthase TR:Q9F847 (EMBL:AF262754) (1265 aa) fasta scores: E(): 7.7e-61, 31.042% id in 902 aa.
   
   0.746
pheS
Similar to Mycobacterium tuberculosis phenylalanyl-tRNA synthetase alpha chain PheS or Rv1649 or MT1687 or MTCY06H11.14 SWALL:SYFA_MYCTU (SWALL:P94984) (341 aa) fasta scores: E(): 6.6e-87, 62.35% id in 340 aa, and to Bacillus subtilis phenylalanyl-tRNA synthetase alpha chain PheS SWALL:SYFA_BACSU (SWALL:P17921) (344 aa) fasta scores: E(): 2.6e-54, 44.02% id in 343 aa, and to Escherichia coli phenylalanyl-tRNA synthetase alpha chain PheS or B1714 SWALL:SYFA_ECOLI (SWALL:P08312) (327 aa) fasta scores: E(): 7.1e-52, 44.71% id in 331 aa; Belongs to the class-II aminoacyl-tRNA synthetase fa [...]
  
  
 0.740
leuS
Similar to Escherichia coli leucyl-tRNA synthetase LeuS or B0642 SWALL:SYL_ECOLI (SWALL:P07813) (860 aa) fasta scores: E(): 1.9e-37, 37.53% id in 967 aa, and to Streptomyces coelicolor leucyl-tRNA synthetase LeuS SWALL:Q9RDL5 (EMBL:AL136518) (966 aa) fasta scores: E(): 1.6e-209, 59.93% id in 971 aa; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
  
 0.736
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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