STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pheAPrephenate dehydratase; Similar to Corynebacterium glutamicum prephenate dehydratase PheA SW:PHEA_CORGL (P10341) (315 aa) fasta scores: E(): 8.6e-50, 52.75% id in 290 aa, and to Streptomyces coelicolor prephenate dehydratase SCD78.29c TR:Q9ZBX0 (EMBL:AL034355) (310 aa) fasta scores: E(): 6.4e-31, 39.63% id in 270 aa. (284 aa)    
Predicted Functional Partners:
DIP0245
Putative prephenate dehydrogenase; Similar to Mycobacterium tuberculosis CDC1551 prephenate dehydrogenase MT3861 TR:AAK48225 (EMBL:AE007181) (323 aa) fasta scores: E(): 5.5e-49, 52.31% id in 281 aa, and to Bacillus subtilis prephenate dehydrogenase TyrA SW:TYRA_BACSU (P20692) (372 aa) fasta scores: E(): 2.7e-15, 31.9% id in 279 aa.
 
 0.993
DIP0834
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 11.8 kDa protein Rv0948c or MT0975 or MTCY10D7.26 SW:Y948_MYCTU (P71562) (105 aa) fasta scores: E(): 1.6e-14, 62.35% id in 85 aa.
  
 
 0.926
pat
Putative aminotransferase; May catalyze the transamination reaction in phenylalanine biosynthesis; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.909
hisC
Similar to Corynebacterium glutamicum histidinol-phosphate aminotransferase HisC TR:Q9KJU4 (EMBL:AF160478) (366 aa) fasta scores: E(): 1.5e-99, 72.17% id in 363 aa, and to Streptomyces coelicolor histidinol-phosphate aminotransferase HisC or SC4G6.22c SW:HIS8_STRCO (P16246) (369 aa) fasta scores: E(): 3e-79, 57.85% id in 363 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.
  
 
 0.909
DIP1681
Similar to Mycobacterium tuberculosis putative aminotransferase Rv2231c or MT2290 or MTCY427.12c SW:YM31_MYCTU (Q10503) (364 aa) fasta scores: E(): 1.7e-50, 45.67% id in 335 aa and to Salmonella typhimurium CobD TR:P97084 (EMBL:U90625) (364 aa) fasta scores: E(): 3.6e-18, 27.76% id in 335 aa.
  
 
 0.909
DIP1790
Glutamine amidotransferase protein; N-terminal region is similar to Streptomyces griseus para-aminobenzoate synthase Pab SW:PABS_STRGR (P32483) (723 aa) fasta scores: E(): 1.8e-48, 39.11% id in 698 aa, and to Streptomyces pristinaespiralis p-aminobenzoate synthase PapA TR:P72539 (EMBL:U60417) (719 aa) fasta scores: E(): 6.1e-43, 35.83% id in 734 aa.
 
  
 0.808
DIP2245
Similar to Mycobacterium leprae putative phosphoglycerate mutase ML0079 TR:Q9CDC3 (EMBL:AL583917) (231 aa) fasta scores: E(): 4e-11, 33.64% id in 214 aa, and to Schizosaccharomyces pombe phosphoglycerate mutase Gpm1 or SPAC26F1.06 SW:PMGY_SCHPO (P36623) (211 aa) fasta scores: E(): 0.28, 24.4% id in 209 aa.
       0.791
DIP1347
Similar to Mycobacterium leprae putative shikimate 5-dehydrogenase AroE or ML0515 SWALL:Q9CCS7 (EMBL:AL583918) (278 aa) fasta scores: E(): 5e-33, 45.42% id in 273 aa, and to Bacillus subtilis shikimate 5-dehydrogenase AroD SWALL:AROE_BACSU (SWALL:P54374) (280 aa) fasta scores: E(): 1.2e-13, 28.36% id in 282 aa.
 
   
 0.742
trpC1
Similar to Corynebacterium glutamicum tryptophan biosynthesis protein TrpCF [includes: indole-3-glycerol phosphate synthase trpC SW:TRPC_CORGL (P06560) (474 aa) fasta scores: E(): 7.5e-121, 70.15% id in 459 aa, and to Escherichia coli tryptophan biosynthesis protein TrpCF [includes: indole-3-glycerol phosphate synthase TrpC or b1262 SW:TRPC_ECOLI (P00909) (452 aa) fasta scores: E(): 3.9e-58, 41.7% id in 482 aa. Note overlap with upstream gene suggesting possible downstream translational start codon; Belongs to the TrpF family.
  
  
 0.727
DIP2247
Putative amidase; Similar to Rhodococcus sp enantiomerase-selective amidase AmdA TR:Q53116 (EMBL:M74531) (462 aa) fasta scores: E(): 6.2e-15, 30.19% id in 414 aa, and to Mycobacterium smegmatis nicotinamidase/pyrazinamidase PzaA TR:Q9ZHK8 (EMBL:AF058285) (468 aa) fasta scores: E(): 6.4e-14, 30.55% id in 360 aa, and to Rhodococcus erythropolis amidase AmdA SW:AMID_RHOER (P22984) (520 aa) fasta scores: E(): 2.8e-11, 33.61% id in 238 aa; Belongs to the amidase family.
  
    0.715
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.