STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (305 aa)    
Predicted Functional Partners:
nadB
Putative aspartate oxidase; Member of a large family of including Sulfolobus solfataricus aspartate oxidase NadB or SSO0997 TR:Q97ZC5 (EMBL:AE006719) (487 aa) fasta scores: E(): 1.4e-18, 36.79% id in 405 aa, and to Streptomyces coelicolor L-aspartate oxidase SCE94.33c TR:Q9X8N8 (EMBL:AL049628) (580 aa) fasta scores: E(): 2.1e-15, 39.6% id in 409 aa.
 
 0.999
nadC
Similar to Mycobacterium tuberculosis nicotinate-nucleotide pyrophosphorylase [carboxylating] NadC or Rv1596 or MT1632 or MTCY336.08c SWALL:NADC_MYCTU (SWALL:O06594) (285 aa) fasta scores: E(): 2.1e-43, 51.09% id in 274 aa, and to Salmonella typhimurium nicotinate-nucleotide pyrophosphorylase [carboxylating] NadC or STM0145 SWALL:NADC_SALTY (SWALL:P30012) (296 aa) fasta scores: E(): 1.6e-34, 41.17% id in 272 aa; Belongs to the NadC/ModD family.
 
 
 0.999
DIP2256
Conserved hypothetical protein; Similar to many eg. Mycobacterium tuberculosis hypothetical 25.9 kDa protein Rv1593c or MT1629 or MTCY336.11 TR:O06597 (EMBL:Z95586) (236 aa) fasta scores: E(): 1.2e-20, 37.28% id in 228 aa. Note possible alternative translational start site.
 
    0.948
DIP0883
Putative membrane protein; Low similarity to Escherichia coli protein PnuC or B0751 SW:PNUC_ECOLI (P31215) (239 aa) fasta scores: E(): 5e-07, 23.75% id in 240 aa.
  
  
 0.776
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
    0.754
DIP2009
Putative peptide synthase; N-terminal region similar to C-terminal region of Streptomyces lavendulae peptide synthetase SWALL:AAK81825 (EMBL:AF386507) (1531 aa) fasta scores: E(): 1.3e-38, 34.02% id in 814 aa, similar in its full length to Agrobacterium tumefaciens StrC58 AGR_l_3476p SWALL:AAK90311 (EMBL:AE008376) (1344 aa) fasta scores: E(): 6.2e-36, 32.96% id in 1338 aa, and N-terminal region similar to the full length of Amycolatopsis orientalis PCZA361.18 SWALL:O52803 (EMBL:AJ223998) (580 aa) fasta scores: E(): 1.3e-33, 38.2% id in 589 aa. C-terminal region presents low similarity [...]
  
    0.722
cysE
Similar to Staphylococcus xylosus serine acetyltransferase CysE SW:CYSE_STAXY (P77985) (216 aa) fasta scores: E(): 9.3e-33, 55.68% id in 167 aa, and to Azotobacter vinelandii O-acetylserine synthase CysE2 TR:O69218 (EMBL:AF010139) (251 aa) fasta scores: E(): 6.1e-38, 58.85% id in 175 aa.
  
    0.688
valS
valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
      0.682
ribD
Putative riboflavin biosynthesis protein; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.667
thiC
Thiamine biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family.
  
  
 0.621
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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