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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2268Similar to Streptomyces coelicolor putative two component system histidine kinase SC10A9.11 SWALL:Q9AK93 (EMBL:AL583943) (404 aa) fasta scores: E(): 7.7e-36, 37.15% id in 401 aa, and to Corynebacterium diphtheriae histidine kinase ChrS (DIP2326) SWALL:Q9RPF0 (EMBL:AF161327) (417 aa) fasta scores: E(): 8.2e-25, 31.17% id in 401 aa. (459 aa)    
Predicted Functional Partners:
DIP2267
Similar to Streptomyces coelicolor putative two component system DNA binding response regulator SC10A9.12 SWALL:Q9AK92 (EMBL:AL583943) (211 aa) fasta scores: E(): 7.7e-38, 59.24% id in 211 aa, and to Corynebacterium diphtheriae response regulator ChrA (DIP2327) SWALL:Q9RPE9 (EMBL:AF161327) (199 aa) fasta scores: E(): 2.1e-21, 49.76% id in 209 aa.
 
 
 0.974
chrA
Two-component response regulator ChrA; Previously sequenced and described as Corynebacterium diphtheriae response regulator ChrA SWALL:Q9RPE9 (EMBL:AF161327) (199 aa) fasta scores: E(): 2.7e-67, 98.49% id in 199 aa. Similar to many eg. Streptomyces reticuli response regulatory protein SenR SWALL:Q9RIM0 (EMBL:Y14336) (217 aa) fasta scores: E(): 1.5e-28, 49.51% id in 204 aa.
 
 
 0.908
DIP0091
Putative two-component system response regulator; Similar to Streptomyces lividans response regulator homolog TR:P72471 (EMBL:U63847) (225 aa) fasta scores: E(): 2.7e-29, 42.98% id in 221 aa, and to Streptomyces coelicolor putative two-component system regulator SCH10.18c TR:Q9X8Q7 (EMBL:AL049754) (228 aa) fasta scores: E(): 3e-26, 38.53% id in 218 aa.
 
   0.833
cstA
Response regulator; Identical to previously sequenced Corynebacterium diphtheriae response regulator CstA TR:Q9RPE7 (EMBL:AF161328) (233 aa) fasta scores: E(): 4.9e-83, 99.57% id in 233 aa.
 
   0.832
DIP0600
Similar to Streptomyces coelicolor putative two-component system DNA-binding response regulator SSCD63A.03 TR:Q9KY72 (EMBL:AL356832) (251 aa) fasta scores: E(): 3.8e-26, 58.72% id in 235 aa, and to Bacillus brevis transcriptional regulatory protein DegU SW:DEGU_BACBR (P54662) (236 aa) fasta scores: E(): 2.7e-10, 30.97% id in 226 aa.
 
   0.826
DIP0092
Similar to Streptomyces coelicolor putative two component sensor kinase SC5F7.35c TR:Q9S2S0 (EMBL:AL096872) (416 aa) fasta scores: E(): 2.9e-17, 32.79% id in 308 aa, and to Streptomyces coelicolor putative two-component system sensor kinase SCH10.17c TR:Q9X8Q6 (EMBL:AL049754) (472 aa) fasta scores: E(): 1.1e-11, 33.61% id in 241 aa.
  
     0.736
DIP2269
Hypothetical protein; No significant database matches.
       0.697
hemA
Putative glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
      
 0.502
DIP2324
Similar to Streptomyces coelicolor putative ABC transport system transmembrane protein SC10A9.10c SWALL:Q9AK94 (EMBL:AL583943) (379 aa) fasta scores: E(): 4.3e-17, 38.94% id in 380 aa. Lies alongside a putative ABC transporter ATP-binding subunit.
 
     0.402
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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