STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2284Putative thioredoxin; Similar to Streptomyces coelicolor thioredoxin TrxA2 SWALL:Q9RD25 (EMBL:AL133422) (134 aa) fasta scores: E(): 1.7e-23, 52.89% id in 121 aa, and to Escherichia coli thioredoxin 2 TrxC or B2582 or Z3867 or ECS3448 SWALL:THI2_ECOLI (SWALL:P33636) (139 aa) fasta scores: E(): 5.9e-11, 38% id in 100 aa; Belongs to the thioredoxin family. (127 aa)    
Predicted Functional Partners:
trxB
Thioredoxin reductase; Similar to Mycobacterium smegmatis thioredoxin reductase TrxB SW:TRXB_MYCSM (O30973) (311 aa) fasta scores: E(): 3.1e-72, 64.82% id in 307 aa.
 
 
 0.884
DIP0823
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT3292 TR:AAK47635 (EMBL:AE007142) (84 aa) fasta scores: E(): 4.4e-12, 48.1% id in 79 aa.
     
 0.707
DIP1494
Similar to Mycobacterium tuberculosis glutathione reductase homolog GorA or Rv2855 or MTCY24A1.02c TR:O07927 (EMBL:AF002193) (459 aa) fasta scores: E(): 4.1e-91, 56.18% id in 461 aa, and to Staphylococcus aureus mercuric reductase MerA SW:MERA_STAAU (P08663) (547 aa) fasta scores: E(): 4.7e-36, 30.17% id in 464 aa.
  
 
 0.691
nrdE
Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
  
 
 0.681
DIP2285
Putative cation transport protein; Similar to Streptomyces coelicolor putative metal associated protein SCG20A.25 SWALL:Q9K3L5 (EMBL:AL360055) (77 aa) fasta scores: E(): 1.3e-05, 45.9% id in 61 aa, and to Helicobacter felis cop associated protein CopP SWALL:COPP_HELFE (SWALL:O32620) (66 aa) fasta scores: E(): 0.0074, 36.92% id in 65 aa.
  
  
 0.658
DIP2282
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis 35 kDa protein Rv2744c or MT2815 or MTV002.09c SWALL:35KD_MYCTU (SWALL:P31511) (270 aa) fasta scores: E(): 8.4e-29, 45.52% id in 257 aa.
       0.626
DIP2286
Similar to Streptomyces coelicolor probable cation-transporting P-type ATPase SCC57A.02 SWALL:Q9RDJ4 (EMBL:AL136519) (760 aa) fasta scores: E(): 7e-146, 60.21% id in 744 aa, and to Rhizobium meliloti copper-transporting ATPase ActP SWALL:ATCU_RHIME (SWALL:Q9X5X3) (827 aa) fasta scores: E(): 1.3e-84, 42.12% id in 762 aa.
 
  
 0.616
DIP0411
Putative electron transport related protein; Similar to Deinococcus radiodurans thiol:disulfide interchange protein DR0189 TR:Q9RXW6 (EMBL:AE001881) (185 aa) fasta scores: E(): 7.1e-09, 34.84% id in 132 aa, and to Bacillus halodurans thioredoxin BH1522 TR:Q9KCP7 (EMBL:AP001512) (177 aa) fasta scores: E(): 3.4e-08, 34.12% id in 126 aa and to Mycobacterium tuberculosis CDC1551 conserved hypothetical protein MT0548 TR:AAK44771 (EMBL:AE006954) (216 aa) fasta scores: E(): 9.2e-31, 48.95% id in 192 aa.
 
  
 0.593
DIP1497
Putative secreted penicillin-binding protein; Similar to Mycobacterium tuberculosis penecillin binding protein Rv2864c or MTV003.10c TR:O33346 (EMBL:AL008883) (603 aa) fasta scores: E(): 1.9e-81, 42.81% id in 612 aa, and to Staphylococcus aureus beta-lactam-inducible penicillin-binding protein Pbp SW:PBP_STAAU (P07944) (670 aa) fasta scores: E(): 2.3e-07, 21.04% id in 632 aa.
    
 
 0.587
dirA
Almost identical to previously sequenced Corynebacterium diphtheriae iron repressible polypeptide DirA TR:Q46025 (EMBL:U18620) (198 aa) fasta scores: E(): 8.8e-79, 98.99% id in 198 aa, and to Mycobacterium smegmatis alkyl hydroperoxide reductase C AhpC TR:Q57529 (EMBL:U43719) (195 aa) fasta scores: E(): 5.2e-52, 66.12% id in 186 aa.
  
 
 0.572
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.