Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DIP2303Putative DNA protection during starvation protein; Similar to Haemophilus ducreyi fine tangled pili major subunit FtpA SWALL:FTPA_HAEDU (SWALL:Q47953) (189 aa) fasta scores: E(): 3.5e-23, 46.83% id in 158 aa, and to Escherichia coli DNA protection during starvation protein Dps or Pexb or Vtm or B0812 or Z1034 or ECS0890 SWALL:DPS_ECOLI (SWALL:P27430) (166 aa) fasta scores: E(): 1.6e-14, 38.31% id in 154 aa; Belongs to the Dps family. (161 aa)    
Predicted Functional Partners:
clpS
Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
   
 
 0.832
DIP2304
Similar to Streptomyces coelicolor putative DNA repair hydrolase SCC80.11c SWALL:Q9F308 (EMBL:AL442143) (306 aa) fasta scores: E(): 1.1e-52, 53.22% id in 295 aa, and to Escherichia coli formamidopyrimidine-DNA glycosylase MutM or Fpg or B3635 SWALL:FPG_ECOLI (SWALL:P05523) (269 aa) fasta scores: E(): 1.2e-12, 29.21% id in 243 aa; Belongs to the FPG family.
     
 0.752
sdaC
Similar to Escherichia coli serine transporter SdaC or DcrA or B2796 or Z4113 or ECS3656 SW:SDAC_ECOLI (P36559) (429 aa) fasta scores: E(): 4.6e-100, 61.66% id in 420 aa.
  
 
   0.664
dirA
Almost identical to previously sequenced Corynebacterium diphtheriae iron repressible polypeptide DirA TR:Q46025 (EMBL:U18620) (198 aa) fasta scores: E(): 8.8e-79, 98.99% id in 198 aa, and to Mycobacterium smegmatis alkyl hydroperoxide reductase C AhpC TR:Q57529 (EMBL:U43719) (195 aa) fasta scores: E(): 5.2e-52, 66.12% id in 186 aa.
  
  
 0.616
nnrE
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
       0.574
hpf
Conserved hypothetical protein; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth.
   
    0.562
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
   
 0.453
xerC
Putative integrase/recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
      
 0.405
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.