STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2304Similar to Streptomyces coelicolor putative DNA repair hydrolase SCC80.11c SWALL:Q9F308 (EMBL:AL442143) (306 aa) fasta scores: E(): 1.1e-52, 53.22% id in 295 aa, and to Escherichia coli formamidopyrimidine-DNA glycosylase MutM or Fpg or B3635 SWALL:FPG_ECOLI (SWALL:P05523) (269 aa) fasta scores: E(): 1.2e-12, 29.21% id in 243 aa; Belongs to the FPG family. (284 aa)    
Predicted Functional Partners:
mutM
Putative formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
 0.984
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
 
  
 0.898
nnrE
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
       0.799
DIP2303
Putative DNA protection during starvation protein; Similar to Haemophilus ducreyi fine tangled pili major subunit FtpA SWALL:FTPA_HAEDU (SWALL:Q47953) (189 aa) fasta scores: E(): 3.5e-23, 46.83% id in 158 aa, and to Escherichia coli DNA protection during starvation protein Dps or Pexb or Vtm or B0812 or Z1034 or ECS0890 SWALL:DPS_ECOLI (SWALL:P27430) (166 aa) fasta scores: E(): 1.6e-14, 38.31% id in 154 aa; Belongs to the Dps family.
     
 0.739
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
   
  
 0.662
DIP0827
Similar to Escherichia coli probable ATP-dependent helicase Lhr or RhlF or B1653 SW:LHR_ECOLI (P30015) (1538 aa) fasta scores: E(): 1.4e-134, 46.42% id in 1579 aa.
  
  
 0.601
coaE
dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.
  
  
 0.482
DIP2272
Possible sortase-like protein; Similar to Clostridium acetobutylicum sortase CAC0204 TR:AAK78186 (EMBL:AE007533) (194 aa) fasta scores: E(): 2.6e-06, 30.872% id in 149 aa, and weakly similar to Actinomyces naeslundii putative fimbria-associated protein TR:O68213 (EMBL:AF019629) (365 aa) fasta scores: E(): 0.25, 32.941% id in 85 aa, and to Streptococcus pneumoniae TIGR4 sortase, putative SP0466 TR:AAK74626 (EMBL:AE007358) (279 aa) fasta scores: E(): 5.3, 25.000% id in 144 aa.
      
 0.468
DIP0586
Putative siderophore biosynthesis related protein; Similar in its N-terminal region and C-terminal region to Rhizobium sp hypothetical 71.0 kDa protein Y4xN SW:Y4XN_RHISN (P55706) blast scores: E(): 3e-23, score: 277 22% id and also to Rhizobium meliloti rhizobactin siderophore biosynthesis protein RhbC or RhsC or RA1260 or SMA2404 SWALL:AAK65918 (EMBL:AF110737) (585 aa) fasta scores: E(): 6e-12, 26.23% id in 526 aa. Possible duplication.
      
 0.426
xerC
Putative integrase/recombinase; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
   
  
 0.414
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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