Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
DIP2313Putative type I restriction/modification system DNA specificity protein; Similar to Lactococcus lactis HsdS subunit SWALL:O68173 (EMBL:AF013596) (395 aa) fasta scores: E(): 2.7e-13, 33.72% id in 172 aa, and to Streptococcus thermophilus putative type I S-subunit protein HsdS SWALL:O52188 (EMBL:AF027167) (412 aa) fasta scores: E(): 1.6e-12, 27.84% id in 334 aa. (414 aa)    
Predicted Functional Partners:
DIP2314
Putative type I restriction/modification system DNA methylase; Similar to Klebsiella pneumoniae HsdM SWALL:O34139 (EMBL:U93843) (539 aa) fasta scores: E(): 6.2e-66, 45.37% id in 551 aa, and to Pasteurella multocida HsdM or PM1537 SWALL:Q9CKR9 (EMBL:AE006190) (568 aa) fasta scores: E(): 2e-51, 44.38% id in 561 aa.
 
 
 0.998
DIP2312
Putative type I restriction/modification system protein; Subunit R is required for both nuclease and ATPase activities, but not for modification.
 
  
 0.992
DIP2315
Hypothetical DNA-binding protein; No significant database matches.
 
 
 0.991
DIP1756
Putative DNA methyltransferase; Similar to Neisseria meningitidis hypothetical protein NMA1791 TR:Q9JTG2 (EMBL:AL162757) (803 aa) fasta scores: E(): 1.8e-94, 40.58% id in 818 aa, and to Deinococcus radiodurans DNA modification methyltransferase-related protein DR2267 TR:Q9RS60 (EMBL:AE002059) (840 aa) fasta scores: E(): 1.8e-15, 25.93% id in 879 aa.
  
 
 0.929
DIP2311
Conserved hypothetical protein; Similar to Deinococcus radiodurans ATP-dependent DNA helicase RecG-related protein DR2199 SWALL:Q9RSC6 (EMBL:AE002053) (596 aa) fasta scores: E(): 1.1e-09, 27.17% id in 574 aa, and to Thiobacillus ferrooxidans ATP-dependent DNA helicase RecG SWALL:RECG_THIFE (SWALL:O50224) (652 aa) fasta scores: E(): 7.7e-05, 33.08% id in 133 aa.
       0.556
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.456
atpF
ATP synthase B chain; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.
   
 
 0.443
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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