STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2325Putative surface-anchored protein; No significant database matches. Note: Contains a potential sortase anchor site (LAETG) upstream of the C-terminal region transmembrane domain. Also similar to DIP0439, DIP1724, DIP0442 and DIP0443. (879 aa)    
Predicted Functional Partners:
DIP0438
Putative secreted protein; C-terminal similar to Bacillus halodurans surface adhesin A precursor PsaA or BH0516 TR:Q9KFG3 (EMBL:AP001508) (300 aa) fasta scores: E(): 2.9e-14, 34.09% id in 176 aa; Belongs to the bacterial solute-binding protein 9 family.
 
   
 0.882
DIP0440
Similar to Deinococcus radiodurans manganese ABC transporter, ATP-binding protein, putative DR2284 TR:Q9RS43 (EMBL:AE002060) (239 aa) fasta scores: E(): 5.3e-25, 39.57% id in 235 aa.
 
   
 0.773
DIP2323
Similar to Streptomyces coelicolor putative ABC transport system ATP-binding protein SC10A9.09c SWALL:Q9AK95 (EMBL:AL583943) (251 aa) fasta scores: E(): 4.7e-31, 51.35% id in 222 aa.
     
 0.749
DIP0441
Putative membrane protein; Similar to Streptococcus gordonii challis 29 kDa membrane protein in psaA 5'region SW:P29K_STRGC (P42361) (278 aa) fasta scores: E(): 3.8e-28, 38.25% id in 264 aa.
 
   
 0.712
DIP0331
Conserved hypothetical protein; Similar to Klebsiella oxytoca YiaX1 TR:AAK69523 (EMBL:AF282849) (315 aa) fasta scores: E(): 4.4e-18, 31.94% id in 313 aa.
  
     0.550
chrS
Two-component system histidine kinase ChrS; Previously sequenced and described as Corynebacterium diphtheriae histidine kinase ChrS SWALL:Q9RPF0 (EMBL:AF161327) (417 aa) fasta scores: E(): 4e-136, 88.72% id in 417 aa. Similar to many eg. Streptomyces reticuli histidine autokinase SenS SWALL:Q9RIM1 (EMBL:Y14336) (398 aa) fasta scores: E(): 1.6e-21, 35.28% id in 411 aa.
       0.548
chrA
Two-component response regulator ChrA; Previously sequenced and described as Corynebacterium diphtheriae response regulator ChrA SWALL:Q9RPE9 (EMBL:AF161327) (199 aa) fasta scores: E(): 2.7e-67, 98.49% id in 199 aa. Similar to many eg. Streptomyces reticuli response regulatory protein SenR SWALL:Q9RIM0 (EMBL:Y14336) (217 aa) fasta scores: E(): 1.5e-28, 49.51% id in 204 aa.
       0.548
DIP1486
Putative cobalamin synthesis related protein; Similar to Staphylococcus aureus (strain N315) hypothetical protein SA0410 or SAV0450 TR:BAB56612 (EMBL:AP003130) (400 aa) fasta scores: E(): 4.2e-50, 48.16% id in 326 aa, and to Pseudomonas denitrificans CobW protein SW:COBW_PSEDE (P29937) (353 aa) fasta scores: E(): 1.1e-19, 29.22% id in 349 aa.
      
 0.514
cas9
Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans- encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. [...]
  
     0.507
DIP0173
Putative membrane protein; Similar to Neisseria meningitidis putative periplasmic binding protein NMA0789 SWALL:Q9JVL4 (EMBL:AL162754) (308 aa) fasta scores: E(): 2.7e-24, 31.71% id in 309 aa, and to Treponema pallidum periplasmic zinc-binding protein TroA or TroMP1 or TP0163 SWALL:TROA_TREPA (SWALL:P96116) (308 aa) fasta scores: E(): 2.5e-16, 33.12% id in 317 aa, and to Streptococcus pyogenes zinc-binding protein precursor AdcA or SPY0714 SWALL:Q9A0L9 (EMBL:AE006523) (515 aa) fasta scores: E(): 2.5e-16, 28.85% id in 298 aa Note: Also similar to the upstream DIP0169, (321 aa) E(): 4.5e [...]
     
 0.502
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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