STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
panCPantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (286 aa)    
Predicted Functional Partners:
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
  
 0.997
DIP1993
Conserved hypothetical protein; C-terminus is similar to the C-terminal region of Lotus japonicus pantoate--beta-alanine ligase precursor PanC SW:PANC_LOTJA (O24035) (307 aa) fasta scores: E(): 4.4e-07, 28.11% id in 217 aa. Similar to the Mycobacterium tuberculosis pantoate--beta-alanine ligase Rv3602c SW:PANC_MYCTU (O06280) (309 aa) fasta scores: E(): 4.7e-19, 38.62% id in 277 aa; Belongs to the pantothenate synthetase family.
  
  
 
0.928
DIP0950
Putative oxidoreductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
    
 0.912
coaA
Pantothenate kinase; Similar to Escherichia coli pantothenate kinase CoaA or Rts or PanK or B3974 or Z5545 or ECS4901 SW:COAA_ECOLI (P15044) (316 aa) fasta scores: E(): 7.4e-62, 52.27% id in 308 aa, and to Mycobacterium tuberculosis pantothenate kinase CoaA or Rv1092c or MT1124 or MTV017.45C SW:COAA_MYCTU (O53440) (312 aa) fasta scores: E(): 1e-76, 64.42% id in 312 aa.
     
 0.907
cmk
Cytidylate kinase; Similar to Mycobacterium tuberculosis cytidylate kinase Cmk or Rv1712 or MT1752 or MTCI125.34 SWALL:KCY_MYCTU (SWALL:O33211) (230 aa) fasta scores: E(): 1.9e-35, 55.45% id in 220 aa, and to Escherichia coli cytidylate kinase Cmk or MssA or B0910 or Z1256 or ECS0993 SWALL:KCY_ECOLI (SWALL:P23863) (227 aa) fasta scores: E(): 9.7e-25, 43.54% id in 209 aa.
      0.903
DIP2356
Similar to Neisseria meningitidis putative membrane protein NMA0754 TR:Q9JVP6 (EMBL:AL162754) (119 aa) fasta scores: E(): 3.9e-14, 47.67% id in 86 aa, and to Escherichia coli, and hypothetical protein YanB or B0468 or Z0585 or ECS0521 SW:YBAN_ECOLI (P45808) (125 aa) fasta scores: E(): 1.2e-10, 37.83% id in 111 aa.
       0.773
ilvA
Threonine dehydratase biosynthetic; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
   
  
 0.630
trpD
Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA).
     
 0.625
trpC1
Similar to Corynebacterium glutamicum tryptophan biosynthesis protein TrpCF [includes: indole-3-glycerol phosphate synthase trpC SW:TRPC_CORGL (P06560) (474 aa) fasta scores: E(): 7.5e-121, 70.15% id in 459 aa, and to Escherichia coli tryptophan biosynthesis protein TrpCF [includes: indole-3-glycerol phosphate synthase TrpC or b1262 SW:TRPC_ECOLI (P00909) (452 aa) fasta scores: E(): 3.9e-58, 41.7% id in 482 aa. Note overlap with upstream gene suggesting possible downstream translational start codon; Belongs to the TrpF family.
     
 0.625
pdxS
Conserved hypothetical protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.
      
 0.597
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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