STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2367Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 21.8 kDa protein Rv0038 or MT0043 or MTCY10h4.38 SW:Y038_MYCTU (P71608) (202 aa) fasta scores: E(): 4.4e-28, 43.64% id in 181 aa; Belongs to the UPF0301 (AlgH) family. (198 aa)    
Predicted Functional Partners:
nrdE
Ribonucleoside-diphosphate reductase alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
   
 0.991
DIP2365
Similar to Bacillus subtilis branched-chain amino acid transport protein AzlD SW:AZLD_BACSU (O07923) (110 aa) fasta scores: E(): 8.2e-05, 36.27% id in 102 aa.
       0.842
DIP2366
Similar to Bacillus subtilis branched-chain amino acid transport protein AzlC SW:AZLC_BACSU (O07942) (254 aa) fasta scores: E(): 4.2e-14, 29.38% id in 211 aa.
       0.842
DIP2368
Putative tRNA nucleotidyltransferase; Similar to a family of proteins from both prokaryotes and eukaryotes and including poly A polymerases and tRNA nucleotidyl transferases. Since prokaryotes don't generally have poly A tailed mRNAs the prokaryotic proteins are likely to be RNA nucleotidyl transferases. Similar to Mycobacterium tuberculosis PcnA or Rv3907c or MTCY15F10.04 TR:O05438 (EMBL:Z94121) (480 aa) fasta scores: E(): 3.5e-119, 64.61% id in 472 aa, and to Streptomyces coelicolor putative RNA nucleotidyltransferase SCH24.18 TR:Q9X8T2 (EMBL:AL049826) (483 aa) fasta scores: E(): 1.3 [...]
       0.842
DIP2370
Putative secreted protein; Weak but full length similarity to Mycobacterium tuberculosis hypothetical 83.9 kDa protein Rv3909 or MTCY15F10.02c TR:O05436 (EMBL:Z94121) (802 aa) fasta scores: E(): 8.4e-10, 25.54% id in 916 aa.
 
     0.723
DIP0619
Putative diphtheria toxin repressor 2; Similar to Mycobacterium tuberculosis iron-dependent repressor IdeR or DtxR or Rv2711 or MT2784 or MTCY05A6.32 SW:IDER_MYCTU (Q50495) (230 aa) fasta scores: E(): 1.1e-10, 31.84% id in 201 aa and low similarity to Corynebacterium diphtheriae diphtheria toxin repressor DtxR SW:DTXR_CORDI (P33120) (226 aa) fasta scores: E(): 7.7e-08, 35.08% identity in 114 aa overlap.
  
    0.706
DIP1349
Conserved hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF nuclease family.
  
  
 0.698
DIP2369
Conserved hypothetical protein; Extensive (but not full length) similarity to Mycobacterium tuberculosis hypothetical 27.1 kDa protein Rv3908 or MTCY15f10.03C TR:O05437 (EMBL:Z94121) (248 aa) fasta scores: E(): 2.3e-25, 47.39% id in 211 aa. Has a hydrophilic N-terminal region; Belongs to the Nudix hydrolase family.
       0.687
DIP1276
Putative secreted protein; Similar to Mycobacterium tuberculosis hypothetical 41.2 kDa protein Rv1488 or MT1533.2 or MTCY277.09 SWALL:YE88_MYCTU (SWALL:P71768) (381 aa) fasta scores: E(): 1.4e-79, 62.53% id in 363 aa, and to Pyrococcus abyssi stomatin-like protein PAB1324 SWALL:Q9UYE4 (EMBL:AJ248288) (299 aa) fasta scores: E(): 2.7e-35, 42.65% id in 279 aa.
   
    0.678
dnaN
DNA polymerase III, beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of r [...]
   
 
 0.637
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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