STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DIP2372Similar to Pseudomonas fluorescens alternative sigma factor AlgU TR:AAK94006 (EMBL:AF399758) (193 aa) fasta scores: E(): 8.1e-12, 30.1% id in 186 aa, and to Pseudomonas aeruginosa RNA polymerase sigma-H factor AlgU or AlgT or PA0762 SW:RPSH_PSEAE (Q06198) (193 aa) fasta scores: E(): 1.8e-11, 29.03% id in 186 aa; Belongs to the sigma-70 factor family. ECF subfamily. (200 aa)    
Predicted Functional Partners:
DIP0099
Similar to Streptomyces coelicolor putative RNA polymerase sigma factor SCI11.12c TR:Q9S2A7 (EMBL:AL096849) (185 aa) fasta scores: E(): 2.8e-25, 47.36% id in 171 aa, and to Bacillus subtilis RNA polymerase sigma factor SigW SW:SIGW_BACSU (Q45585) (187 aa) fasta scores: E(): 3.9e-10, 31.39% id in 172 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
 0.903
sigB
RNA polymerase sigma factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
   
  
 0.837
sigC
Similar to Mycobacterium tuberculosis probable RNA polymerase sigma-C factor SigC or Rv2069 or MT2129 or MTCY49.08 SW:RPSC_MYCTU (Q10679) (185 aa) fasta scores: E(): 6.1e-30, 52.24% id in 178 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
 0.836
DIP0577
Putative RNA-polymerase sigma factor; Similar to Mycobacterium tuberculosis probable RNA polymerase sigma-D factor SigD or Rv3414c or MT3523 or MTCY78.15 SW:RPSD_MYCTU (Q50712) (212 aa) fasta scores: E(): 7e-28, 48.58% id in 177 aa, and to Streptomyces coelicolor RNA polymerase sigma-E factor SigE or SCE94.07 SW:RPOE_STRCO (P38133) (176 aa) fasta scores: E(): 0.0002, 28.38% id in 155 aa; Belongs to the sigma-70 factor family. ECF subfamily.
  
   
 0.756
trxB
Thioredoxin reductase; Similar to Mycobacterium smegmatis thioredoxin reductase TrxB SW:TRXB_MYCSM (O30973) (311 aa) fasta scores: E(): 3.1e-72, 64.82% id in 307 aa.
     
 0.737
trxA
Thioredoxin; Similar to Mycobacterium smegmatis thioredoxin TrxA SW:THIO_MYCSM (O30974) (112 aa) fasta scores: E(): 5.8e-18, 48.14% id in 108 aa; Belongs to the thioredoxin family.
     
 0.722
DIP2370
Putative secreted protein; Weak but full length similarity to Mycobacterium tuberculosis hypothetical 83.9 kDa protein Rv3909 or MTCY15F10.02c TR:O05436 (EMBL:Z94121) (802 aa) fasta scores: E(): 8.4e-10, 25.54% id in 916 aa.
   
   0.684
DIP2371
Putative conserved integral membrane protein; Similar to Mycobacterium tuberculosis hypothetical 123.6 kDa protein Rv3910 or MTCY15F10.01c or MTV028.01 TR:O05435 (EMBL:Z94121) (1184 aa) fasta scores: E(): 1.1e-83, 35.58% id in 1200 aa, and to Rhizobium tropici virulence factor MviN homolog SW:MVIN_RHITR (O05467) (533 aa) fasta scores: E(): 5.7e-15, 23.87% id in 553 aa.
       0.649
DIP2375
Putative hydrolase; Similar to Mycobacterium tuberculosis putative hydrolase CwlM or Rv3915 or MTV028.06 TR:O53593 (EMBL:AL021426) (406 aa) fasta scores: E(): 5.4e-78, 52.38% id in 399 aa, and to Bacillus subtilis N-acetylmuramoyl-L-alanine amidase CwlB precursor or LytC SW:CWLB_BACSU (Q02114) (496 aa) fasta scores: E(): 2.8e-07, 25.62% id in 199 aa.
  
  
 0.633
DIP2369
Conserved hypothetical protein; Extensive (but not full length) similarity to Mycobacterium tuberculosis hypothetical 27.1 kDa protein Rv3908 or MTCY15f10.03C TR:O05437 (EMBL:Z94121) (248 aa) fasta scores: E(): 2.3e-25, 47.39% id in 211 aa. Has a hydrophilic N-terminal region; Belongs to the Nudix hydrolase family.
  
    0.561
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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