STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rsmGConserved hypothetical protein; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (223 aa)    
Predicted Functional Partners:
parA
Similar to Streptomyces coelicolor chromosome partitioning protein ParA TR:Q9RFM1 (EMBL:AF187159) (357 aa) fasta scores: E(): 2.5e-64, 63.6% id in 294 aa, and to Bacillus subtilis sporulation initiation inhibitor protein Soj SW:SOJ_BACSU (P37522) (253 aa) fasta scores: E(): 2.8e-45, 54.15% id in 253 aa.
  
  
 0.905
parB
Similar to Mycobacterium tuberculosis probable chromosome partitioning protein ParB or Rv3917c or MT4036 or MTV028.08c SW:PARB_MYCTU (O53595) (344 aa) fasta scores: E(): 7.4e-47, 54.93% id in 375 aa, and to Streptomyces coelicolor putative chromosome partitioning protein ParB TR:Q9RFM2 (EMBL:AF187159) (368 aa) fasta scores: E(): 3.2e-43, 47.69% id in 369 aa; Belongs to the ParB family.
  
  
 0.898
rnpA
Conserved hypothetical protein (pseudogene); RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme.
 
  
 0.855
rpsL
30S ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy.
      
 0.839
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
 
 0.826
rpoB
DNA-directed RNA polymerase beta chain; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
  
 0.809
DIP1180
Putative cytotoxin/hemolysin; Similar to Mycobacterium tuberculosis CDC1551 cytotoxin/hemolysin MT1733 SWALL:AAK46002 (EMBL:AE007035) (268 aa) fasta scores: E(): 2.2e-53, 56.56% id in 274 aa, and to Caulobacter crescentus hemolysin A CC1324 SWALL:Q9A8M9 (EMBL:AE005808) (243 aa) fasta scores: E(): 1.2e-29, 42.27% id in 246 aa.
  
   
 0.774
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.765
DIP2379
Similar to Mycobacterium tuberculosis putative membrane protein MTV028.12c Rv3921c or MTV028.12c TR:O53599 (EMBL:AL021426) (366 aa) fasta scores: E(): 5.3e-40, 44.72% id in 313 aa, and to Streptomyces coelicolor inner membrane protein SCH24.05 TR:O54569 (EMBL:Y16311) (431 aa) fasta scores: E(): 2.6e-16, 29.74% id in 279 aa. Questionable translational start as N-terminal region is truncated relative to homologues and the start codon is distant from the likely ribosome binding site. Also C-terminus is truncated relative to homologues and ends with KKKKK.
  
  
 0.762
frr
Ribosome recycling factor; Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another; Belongs to the RRF family.
  
   
 0.650
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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