Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
rnpAConserved hypothetical protein (pseudogene); RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (119 aa)    
Predicted Functional Partners:
rpmH
50S ribosomal protein L34; Similar to Mycobacterium paratuberculosis 50S ribosomal protein L34 RpmH SW:RL34_MYCPA (Q9L7L8) (47 aa) fasta scores: E(): 2.9e-15, 80.85% id in 47 aa, to Streptomyces bikiniensis 50S ribosomal protein L34 RpmH SW:RL34_STRBI (P25820) (45 aa) fasta scores: E(): 2.2e-13, 81.39% id in 43 aa, and to Escherichia coli 50S ribosomal protein L34 Rpmh or SsaF or RimA or B3703 or Z5194 or ECS4638 or STM3839 SW:RL34_ECOLI (P02437) (46 aa) fasta scores: E(): 1.1e-07, 59.52% id in 42 aa; Belongs to the bacterial ribosomal protein bL34 family.
  
  
 0.986
DIP2379
Similar to Mycobacterium tuberculosis putative membrane protein MTV028.12c Rv3921c or MTV028.12c TR:O53599 (EMBL:AL021426) (366 aa) fasta scores: E(): 5.3e-40, 44.72% id in 313 aa, and to Streptomyces coelicolor inner membrane protein SCH24.05 TR:O54569 (EMBL:Y16311) (431 aa) fasta scores: E(): 2.6e-16, 29.74% id in 279 aa. Questionable translational start as N-terminal region is truncated relative to homologues and the start codon is distant from the likely ribosome binding site. Also C-terminus is truncated relative to homologues and ends with KKKKK.
  
  
 0.917
rpsP
Similar to Mycobacterium leprae 30S ribosomal protein S16 RpsP or ML1618 or MLCB250.32 SW:RS16_MYCLE (O33014) (160 aa) fasta scores: E(): 8.3e-32, 70.39% id in 152 aa, and to Thermus aquaticus 30S ribosomal protein S16 RpsP or Rps16 SW:RS16_THETH (P80379) (88 aa) fasta scores: E(): 6.1e-11, 52.27% id in 88 aa.
  
  
 0.825
DIP2273
Putative integral membrane protein; Similar to Mycobacterium paratuberculosis hypothetical 39.2 kDa protein SWALL:Q9L7M1 (EMBL:AF222789) (353 aa) fasta scores: E(): 1.2e-16, 32.69% id in 312 aa, and to Streptomyces coelicolor integral membrane protein SCH24.05 SWALL:O54569 (EMBL:Y16311) (431 aa) fasta scores: E(): 0.00015, 23.88% id in 448 aa. Note the overlap with downstream gene.
  
  
 0.821
rpsA
30S ribosomal protein S1; Similar to Corynebacterium ammoniagenes 30s ribosomal protein S1 RpsA SWALL:Q9LBD0 (EMBL:AF045481) (489 aa) fasta scores: E(): 6e-160, 92.18% id in 486 aa, and to Escherichia coli 30S ribosomal protein S1 RpsA or SsyF or B0911 or Z1257 or ECS0994 SWALL:RS1_ECOLI (SWALL:P02349) (557 aa) fasta scores: E(): 2.9e-52, 44.97% id in 358 aa.
  
  
 0.784
rplC
50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
   
  
 0.781
rsmG
Conserved hypothetical protein; Specifically methylates the N7 position of guanine in position 518 of 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
 
  
 0.779
rpmB2
Similar to Mycobacterium tuberculosis 50S ribosomal protein L28-2 RpmB2 or Rv2058c or MT2118 or MTCY63A.02 SW:R28B_MYCTU (O86357) (78 aa) fasta scores: E(): 7.7e-22, 70.51% id in 78 aa; Belongs to the bacterial ribosomal protein bL28 family.
  
  
 0.778
rho
Transcription termination factor Rho homolog; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.
  
  
 0.776
rpsT
30S ribosomal protein S20; Binds directly to 16S ribosomal RNA.
  
    0.776
Your Current Organism:
Corynebacterium diphtheriae
NCBI taxonomy Id: 257309
Other names: C. diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC 13129, Corynebacterium diphtheriae NCTC13129
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