STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BP0628Similar to Zea mays pyruvate dehydrogenase E1 beta subunit isoform 2 Pdh2 TR:Q9ZQY2 (EMBL:AF069909) (374 aa) fasta scores: E(): 4.3e-56, 47.077% id in 325 aa, and to Rhizobium loti acetoin dehydrogenase Mll3628 TR:Q98FT4 (EMBL:AP003002) (332 aa) fasta scores: E(): 3.5e-60, 51.713% id in 321 aa. (324 aa)    
Predicted Functional Partners:
lpdA
Similar to Escherichia coli dihydrolipoamide dehydrogenase LpdA or Lpd or B0116 SW:DLDH_ECOLI (P00391) (473 aa) fasta scores: E(): 4.1e-94, 55.579% id in 466 aa, and to Salmonella enterica subspenterica serovar Typhimurium. dihydrolipoamide dehydrogenase Lpd TR:Q9ACP1 (EMBL:AJ297525) (475 aa) fasta scores: E(): 4.7e-94, 55.246% id in 467 aa.
 
 0.999
pdhA
Putative pyruvate dehydrogenase E1 component, alpha subunit; Similar to Clostridium magnum TPP-dependent acetoin dehydrogenase alpha-subunit TR:Q46142 (EMBL:L31844) (326 aa) fasta scores: E(): 8.2e-48, 43.631% id in 314 aa, and to Pseudomonas aeruginosa probable dehydrogenase e1 component Pa4150 TR:Q9HWN1 (EMBL:AE004831) (324 aa) fasta scores: E(): 3.1e-48, 45.541% id in 314 aa.
 0.999
lpdA-2
Similar to Escherichia coli dihydrolipoamide dehydrogenase LpdA or Lpd or B0116 or Z0126 or ecs0120 SW:DLDH_ECOLI (P00391) (473 aa) fasta scores: E(): 7.8e-97, 63.713% id in 474 aa, and to Alcaligenes eutrophus dihydrolipoamide dehydrogenase PdhL TR:Q59099 (EMBL:U09865) (594 aa) fasta scores: E(): 4.8e-147, 75.541% id in 601 aa.
 
 0.999
odhB
Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2).
 0.989
BP0627
ScanRegExp hit to PS00189, 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. Confirmed by InterPro eMOTIF pattern match.
  
 
 0.987
aceF
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.985
prsA
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 0.977
odhL
2-oxoglutarate dehydrogenase complex, E3 component; Similar to Alcaligenes eutrophus dihydrolipoamide dehydrogenase OdhL SW:DLDH_ALCEU (P52992) (474 aa) fasta scores: E(): 4.8e-107, 60.29% id in 476 aa, and to Neisseria meningitidis putative dihydrolipoamide dehydrogenase e3 component lpda3 or nma1151 TR:Q9JUT1 (EMBL:AL162755) (477 aa) fasta scores: E(): 1.8e-109, 64.34% id in 474 aa.
 
 0.910
gor
Glutathione reductase; Similar to e.g. Pseudomonas aeruginosa glutathione reductase Gor or PA2025 SW:GSHR_PSEAE (P23189) (451 aa) fasta scores: E(): 1.6e-143, 80.44% id in 450 aa, and to Escherichia coli glutathione reductase Gor or b3500 SWALL:GSHR_ECOLI (SWALL:P06715) (450 aa) fasta scores: E(): 2.1e-67, 45.11% id in 450 aa.
 
 0.897
BP1729
Putative pyridine nucleotide-disulfide oxidoreductase; Similar to Halobacterium volcanii dihydrolipoamide dehydrogenase Lpd SW:DLDH_HALVO (Q04829) (474 aa) fasta scores: E(): 1.4e-30, 32.27% id in 471 aa, and to Vibrio cholerae pyridine nucleotide-disulfide oxidoreductase, class I Vc2638 TR:Q9KNU2 (EMBL:AE004330) (484 aa) fasta scores: E(): 1e-102, 60.17% id in 467 aa.
 
 0.880
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.