STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (358 aa)    
Predicted Functional Partners:
proA
Putative gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
 
 0.999
putA
Bifunctional proline oxidoreductase/transcriptional repressor; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family.
    
 0.948
rocD
Ornithine aminotransferase; Catalyzes the interconversion of ornithine to glutamate semialdehyde.
   
 0.921
BP0429
Similar to Homo sapiens delta-1-pyrroline-5-carboxylate dehydrogenase precursor AldH4a1 or P5cdh or AldH4 SW:PUT2_HUMAN (P30038) (563 aa) fasta scores: E(): 7.8e-101, 50.094% id in 531 aa, and to Mycobacterium tuberculosis delta-1-pyrroline-5-carboxylate dehydrogenase RocA or Rv1187 or Mtv005.23 TR:O50443 (EMBL:AL010186) (543 aa) fasta scores: E(): 1.7e-118, 58.868% id in 530 aa.
   
 
 0.904
proC
Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
 
 
 0.867
obg
Probable GTP-binding protein; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.
  
  
 0.813
gltB
Similar to Escherichia coli glutamate synthase [NADPH] large chain precursor GltB SW:GLTB_ECOLI (P09831) (1517 aa) fasta scores: E(): 8.3e-106, 44.45% id in 1597 aa, and to Deinococcus radiodurans glutamate synthase, large subunit DR0183 TR:Q9RXX2 (EMBL:AE001880) (1615 aa) fasta scores: E(): 0, 70.42% id in 1579 aa.
    
 0.720
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
  
 
 0.699
BP2784
Similar to Pseudomonas aeruginosa homoserine dehydrogenase Hom or Pa3736 SW:DHOM_PSEAE (P29365) (434 aa) fasta scores: E(): 2.9e-97, 63.76% id in 436 aa.
 
  
 0.625
pyrG
CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
   
 0.617
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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