STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. (358 aa)    
Predicted Functional Partners:
leuC-2
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
 0.999
leuD-2
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.999
leuD
3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily.
 
 
 0.990
ilvH
Similar to Escherichia coli acetolactate synthase isozyme III small subunit IlvH or BrnP or B0078 SW:ILVH_ECOLI (P00894) (163 aa) fasta scores: E(): 3.7e-31, 55.828% id in 163 aa, and to Neisseria meningitidis acetolactate synthase isozyme III small subunit IlvH or Nma1765 or Nmb1576 TR:Q9JRF4 (EMBL:AL162757) (163 aa) fasta scores: E(): 8.5e-38, 66.871% id in 163 aa.
 
 0.980
ilvI
N-terminal region of a putative membrane protein (Pseudogene); 4 probable transmembrane helices predicted for BP0787 by TMHMM2.0 at aa 21-43, 88-110, 117-139 and 154-176.
 
 0.966
BP0467
Similar to Saccharomyces cerevisiae acetolactate synthase, mitochondrial precursor Ilv2 or Smr1 or Ymr108w or Ym9718.07 SW:ILVB_YEAST (P07342) (687 aa) fasta scores: E(): 1.7e-87, 42.710% id in 583 aa, and to Rhizobium meliloti probable acetolactate synthase isozyme III large subunit protein TR:CAC46693 (EMBL:AL591789) (592 aa) fasta scores: E(): 1.3e-81, 52.860% id in 577 aa. Also similar to BP0789 (50.000% identity in 580 aa overlap).
 
 0.960
tdcB
Similar to Escherichia coli threonine dehydratase catabolic TdcB or B3117 or Z4469 or Ecs3997 SW:THD2_ECOLI (P05792) (329 aa) fasta scores: E(): 1.6e-41, 45.246% id in 305 aa, and to Caulobacter crescentus threonine dehydratase Cc3635 TR:Q9A2D0 (EMBL:AE006022) (400 aa) fasta scores: E(): 4.1e-72, 52.897% id in 397 aa.
 
 
 0.956
BP0860
Similar to Escherichia coli acetolactate synthase isozyme III large subunit IlvI or b0077 SW:ILVI_ECOLI (P00893) (574 aa) fasta scores: E(): 2e-18, 28.571% id in 532 aa, and to Rhizobium meliloti probable AtrC acetolactate syntase AtrC TR:AAK65177 (EMBL:AE007243) (570 aa) fasta scores: E(): 4.3e-100, 50.722% id in 554 aa; Belongs to the TPP enzyme family.
 
 0.947
BP0773
Similar to Methanococcus aeolicus acetohydroxyacid synthase large subunit IlvB TR:O08353 (EMBL:U35458) (599 aa) fasta scores: E(): 2.2e-48, 32.105% id in 570 aa, and to Methanococcus maripaludis acetohydroxyacid synthase large subunit IlvB TR:Q9Y8J0 (EMBL:AF118061) (587 aa) fasta scores: E(): 3.6e-46, 32.737% id in 559 aa; Belongs to the TPP enzyme family.
 
 0.945
ilvB
Similar to Escherichia coli acetolactate synthase isozyme III large subunit IlvI or B0077 SW:ILVI_ECOLI (P00893) (574 aa) fasta scores: E(): 1e-42, 30.515% id in 544 aa, and to Methanococcus aeolicus acetohydroxyacid synthase large subunit IlvB TR:O08353 (EMBL:U35458) (599 aa) fasta scores: E(): 5.4e-59, 34.581% id in 561 aa; Belongs to the TPP enzyme family.
 
 0.945
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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