STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
panBProbable 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (278 aa)    
Predicted Functional Partners:
panC
Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
  
 0.999
panD
Aspartate 1-decarboxylase precursor; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
 
  
 0.992
BP1360
Putative ketopantoate reductase; Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.
    
 0.973
ilvE
Branched-chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family.
  
 
 0.914
BP3571
Putative aminotransferase; Similar to Escherichia coli branched-chain amino acid aminotransferase IlvE SW:ILVE_ECOLI (P00510) (308 aa) fasta scores: E(): 3.2e-12, 26.82% id in 287 aa, and to Rhizobium loti branched-chain amino acid aminotransferase MLR7635 TR:Q985K4 (EMBL:AP003012) (292 aa) fasta scores: E(): 9e-45, 44.64% id in 271 aa. Possible alternative upstream translational start site.
    
 0.914
ilvD
Similar to Escherichia coli dihydroxy-acid dehydratase IlvD or B3771 SW:ILVD_ECOLI (P05791) (616 aa) fasta scores: E(): 9.7e-180, 75.041% id in 617 aa, and to Neisseria meningitidis dihydroxy-acid dehydratase Nmb1188 or Nmb1150 TR:Q9JS61 (EMBL:AE002466) (619 aa) fasta scores: E(): 5.7e-183, 73.506% id in 619 aa. Also similar to BP3043, 36.661% identity (40.653% ungapped) in 611 aa overlap; Belongs to the IlvD/Edd family.
   
 
 0.913
ilvD-2
Similar to Lactococcus lactis dihydroxy-acid dehydratase IlvD SW:ILVD_LACLA (Q02139) (570 aa) fasta scores: E(): 5.1e-94, 47.13% id in 558 aa, and to Bacillus subtilis dihydroxy-acid dehydratase IlvD SW:ILVD_BACSU (P51785) (557 aa) fasta scores: E(): 7.9e-87, 43.08% id in 557 aa. Also similar to BP0289, 36.661% identity (40.653% ungapped) in 611 aa overlap; Belongs to the IlvD/Edd family.
     
 0.913
coaD
Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
   
  
 0.768
nadC
Similar to Mycobacterium tuberculosis nicotinate-nucleotide pyrophosphorylase [carboxylating] NadC SW:NADC_MYCTU (O06594) (285 aa) fasta scores: E(): 1.6e-36, 50.18% id in 267 aa, and to Rhizobium loti nicotinate-mononucleotide pyrophosphorylase MLL9102 TR:Q982F4 (EMBL:AP003015) (284 aa) fasta scores: E(): 2.4e-68, 71.11% id in 277 aa. Possible alternative translational start site; Belongs to the NadC/ModD family.
     0.686
gcvP
Glycine cleavage system P protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
  
  
 0.571
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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