STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (211 aa)    
Predicted Functional Partners:
aroB
3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ); Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.
  
 0.999
aroE
Shikimate 5-dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).
 
 0.985
aroA
3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.
 
 
 0.978
aroC
Putative membrane protein (Pseudogene); Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.
 
  
 0.946
aroQ
3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family.
   
 0.927
BP3658
Putative phosphohydrolase; Weakly similar to Escherichia coli deoxyguanosinetriphosphate triphosphohydrolase Dgt SW:DGTP_ECOLI (P15723) (504 aa) fasta scores: E(): 0.00029, 25.37% id in 469 aa. Similar to Caulobacter crescentus putative deoxyguanosinetriphosphate triphosphohydrolase CC2008 TR:Q9A6S5 (EMBL:AE005874) (394 aa) fasta scores: E(): 4.3e-58, 49.61% id in 385 aa; Belongs to the dGTPase family. Type 2 subfamily.
  
    0.870
pheA
Similar to Escherichia coli P-protein [includes: chorismate mutase and prephenate dehydratase] PheA or B2599 or Z3891 or Ecs3462 SW:PHEA_ECOLI (P07022) (386 aa) fasta scores: E(): 4.9e-27, 33.773% id in 379 aa, and to Neisseria meningitidis chorismate mutase/prephenate dehydratase nmb0446 TR:Q9K0W1 (EMBL:AE002401) (362 aa) fasta scores: E(): 3.3e-66, 50.276% id in 362 aa.
 
  
 0.838
mrcA
Similar to Escherichia coli penicillin-binding protein 1A MrcA or PonA or B3396 SW:PBPA_ECOLI (P02918) (850 aa) fasta scores: E(): 2.1e-61, 37.243% id in 827 aa, and to Pseudomonas aeruginosa penicillin-binding protein 1A MrcA or PonA or Pa5045 SW:PBPA_PSEAE (Q07806) (822 aa) fasta scores: E(): 3.7e-62, 38.882% id in 805 aa.
     
 0.835
tyrA
Similar to Bordetella bronchiseptica prephenate dehydrogenase TyrA TR:Q9RND8 (EMBL:AF182427) (299 aa) fasta scores: E(): 4.1e-108, 99.331% id in 299 aa, and to Rhizobium meliloti putative cyclohexadienyl dehydrogenase and adh prephenate dehydrogenase protein TR:CAC47240 (EMBL:AL591791) (307 aa) fasta scores: E(): 1.2e-33, 43.110% id in 283 aa.
 
  
 0.817
thyA
Putative thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
     
 0.710
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.