node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
guaA | hisA | BP2624 | BP3772 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa. | 0.799 |
guaA | hisF | BP2624 | BP3773 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Histidine biosynthesis protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.501 |
guaA | hisH | BP2624 | BP3771 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.517 |
hisA | guaA | BP3772 | BP2624 | Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.799 |
hisA | hisB | BP3772 | BP3770 | Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa. | Imidazoleglycerol-phosphate dehydratase; Similar to C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein hisB [includes: histidinol-phosphatase and imidazoleglycerolphosphate dehydratase] HisB SW:HIS7_ECOLI (P06987) (355 aa) fasta scores: E(): 3.6e-32, 50% id in 194 aa, and to the full length Pseudomonas aeruginosa imidazoleglycerol-phosphate dehydratase PA5143 TR:Q9HU41 (EMBL:AE004927) (197 aa) fasta scores: E(): 1.7e-56, 74.74% id in 194 aa. | 0.997 |
hisA | hisC | BP3772 | BP3769 | Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa. | Similar to Escherichia coli histidinol-phosphate aminotransferase HisC SW:HIS8_ECOLI (P06986) (356 aa) fasta scores: E(): 2.3e-20, 31.4% id in 363 aa, and to Neisseria meningitidis histidinol-phosphate aminotransferase NMA1771 TR:Q9JTH8 (EMBL:AL162757) (365 aa) fasta scores: E(): 3.7e-48, 40.84% id in 355 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.918 |
hisA | hisD | BP3772 | BP3768 | Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa. | Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
hisA | hisE | BP3772 | BP3775 | Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa. | phosphoribosyl-ATP pyrophosphohydrolase; Similar to the C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein [includes: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase] HisI SW:HIS2_ECOLI (P06989) (203 aa) fasta scores: E(): 0.0074, 32.22% id in 90 aa, and to the full length Neisseria meningitidis putative phosphoribosyl-ATP cyclohydrolase NMA0807 TR:Q9JVJ9 (EMBL:AL162754) (107 aa) fasta scores: E(): 9.6e-18, 53.77% id in 106 aa. | 0.998 |
hisA | hisF | BP3772 | BP3773 | Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa. | Histidine biosynthesis protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | BP3772 | BP3767 | Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa. | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.993 |
hisA | hisH | BP3772 | BP3771 | Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | BP3772 | BP3774 | Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa. | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisA | hisZ | BP3772 | BP2189 | Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa. | Putative tRNA synthetase; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.944 |
hisB | hisA | BP3770 | BP3772 | Imidazoleglycerol-phosphate dehydratase; Similar to C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein hisB [includes: histidinol-phosphatase and imidazoleglycerolphosphate dehydratase] HisB SW:HIS7_ECOLI (P06987) (355 aa) fasta scores: E(): 3.6e-32, 50% id in 194 aa, and to the full length Pseudomonas aeruginosa imidazoleglycerol-phosphate dehydratase PA5143 TR:Q9HU41 (EMBL:AE004927) (197 aa) fasta scores: E(): 1.7e-56, 74.74% id in 194 aa. | Histidine biosynthesis protein; Similar to Escherichia coli phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA SW:HIS4_ECOLI (P10371) (245 aa) fasta scores: E(): 6.9e-21, 33.87% id in 245 aa, and to Neisseria meningitidis putative phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase NMA0839 TR:Q9JVH4 (EMBL:AL162754) (245 aa) fasta scores: E(): 1.3e-62, 69.26% id in 244 aa. | 0.997 |
hisB | hisC | BP3770 | BP3769 | Imidazoleglycerol-phosphate dehydratase; Similar to C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein hisB [includes: histidinol-phosphatase and imidazoleglycerolphosphate dehydratase] HisB SW:HIS7_ECOLI (P06987) (355 aa) fasta scores: E(): 3.6e-32, 50% id in 194 aa, and to the full length Pseudomonas aeruginosa imidazoleglycerol-phosphate dehydratase PA5143 TR:Q9HU41 (EMBL:AE004927) (197 aa) fasta scores: E(): 1.7e-56, 74.74% id in 194 aa. | Similar to Escherichia coli histidinol-phosphate aminotransferase HisC SW:HIS8_ECOLI (P06986) (356 aa) fasta scores: E(): 2.3e-20, 31.4% id in 363 aa, and to Neisseria meningitidis histidinol-phosphate aminotransferase NMA1771 TR:Q9JTH8 (EMBL:AL162757) (365 aa) fasta scores: E(): 3.7e-48, 40.84% id in 355 aa; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | BP3770 | BP3768 | Imidazoleglycerol-phosphate dehydratase; Similar to C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein hisB [includes: histidinol-phosphatase and imidazoleglycerolphosphate dehydratase] HisB SW:HIS7_ECOLI (P06987) (355 aa) fasta scores: E(): 3.6e-32, 50% id in 194 aa, and to the full length Pseudomonas aeruginosa imidazoleglycerol-phosphate dehydratase PA5143 TR:Q9HU41 (EMBL:AE004927) (197 aa) fasta scores: E(): 1.7e-56, 74.74% id in 194 aa. | Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisE | BP3770 | BP3775 | Imidazoleglycerol-phosphate dehydratase; Similar to C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein hisB [includes: histidinol-phosphatase and imidazoleglycerolphosphate dehydratase] HisB SW:HIS7_ECOLI (P06987) (355 aa) fasta scores: E(): 3.6e-32, 50% id in 194 aa, and to the full length Pseudomonas aeruginosa imidazoleglycerol-phosphate dehydratase PA5143 TR:Q9HU41 (EMBL:AE004927) (197 aa) fasta scores: E(): 1.7e-56, 74.74% id in 194 aa. | phosphoribosyl-ATP pyrophosphohydrolase; Similar to the C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein [includes: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphatase] HisI SW:HIS2_ECOLI (P06989) (203 aa) fasta scores: E(): 0.0074, 32.22% id in 90 aa, and to the full length Neisseria meningitidis putative phosphoribosyl-ATP cyclohydrolase NMA0807 TR:Q9JVJ9 (EMBL:AL162754) (107 aa) fasta scores: E(): 9.6e-18, 53.77% id in 106 aa. | 0.993 |
hisB | hisF | BP3770 | BP3773 | Imidazoleglycerol-phosphate dehydratase; Similar to C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein hisB [includes: histidinol-phosphatase and imidazoleglycerolphosphate dehydratase] HisB SW:HIS7_ECOLI (P06987) (355 aa) fasta scores: E(): 3.6e-32, 50% id in 194 aa, and to the full length Pseudomonas aeruginosa imidazoleglycerol-phosphate dehydratase PA5143 TR:Q9HU41 (EMBL:AE004927) (197 aa) fasta scores: E(): 1.7e-56, 74.74% id in 194 aa. | Histidine biosynthesis protein; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | BP3770 | BP3767 | Imidazoleglycerol-phosphate dehydratase; Similar to C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein hisB [includes: histidinol-phosphatase and imidazoleglycerolphosphate dehydratase] HisB SW:HIS7_ECOLI (P06987) (355 aa) fasta scores: E(): 3.6e-32, 50% id in 194 aa, and to the full length Pseudomonas aeruginosa imidazoleglycerol-phosphate dehydratase PA5143 TR:Q9HU41 (EMBL:AE004927) (197 aa) fasta scores: E(): 1.7e-56, 74.74% id in 194 aa. | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.997 |
hisB | hisH | BP3770 | BP3771 | Imidazoleglycerol-phosphate dehydratase; Similar to C-terminal region of Escherichia coli histidine biosynthesis bifunctional protein hisB [includes: histidinol-phosphatase and imidazoleglycerolphosphate dehydratase] HisB SW:HIS7_ECOLI (P06987) (355 aa) fasta scores: E(): 3.6e-32, 50% id in 194 aa, and to the full length Pseudomonas aeruginosa imidazoleglycerol-phosphate dehydratase PA5143 TR:Q9HU41 (EMBL:AE004927) (197 aa) fasta scores: E(): 1.7e-56, 74.74% id in 194 aa. | Amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |