STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
BP3847Similar to Homo sapiens mitochondrial hydroxymethylglutaryl-CoA lyase precursor HMGCL SW:HMGL_HUMAN (P35914) (325 aa) fasta scores: E(): 4.7e-18, 35.94% id in 306 aa, and to Pseudomonas mevalonii hydroxymethylglutaryl-CoA lyase MvaB SW:HMGL_PSEMV (P13703) (301 aa) fasta scores: E(): 7.2e-17, 36.03% id in 308 aa. (335 aa)    
Predicted Functional Partners:
BP3848
Putative enoyl-CoA hydratase/isomerase; Similar to Mus musculus AU-binding enoyl-CoA hydratase AUH TR:Q9JLZ3 (EMBL:AF118386) (314 aa) fasta scores: E(): 4.3e-15, 30.15% id in 262 aa, and to Mycobacterium tuberculosis hypothetical protein MTCY08D5.17 TR:P96404 (EMBL:Z92669) (262 aa) fasta scores: E(): 4.3e-23, 39.6% id in 250 aa.
  
 0.846
accB
Similar to Myxococcus xanthus acetyl-CoA carboxylase carboxyltransferase AccB TR:Q9FAF6 (EMBL:AB039884) (538 aa) fasta scores: E(): 1.7e-93, 47.330% id in 543 aa, and to Homo sapiens 3-methylcrotonyl-Coa carboxylase subunit MccB TR:AAK49409 (EMBL:AF261884) (563 aa) fasta scores: E(): 8.1e-142, 68.182% id in 528 aa.
 
 
 0.750
BP1702
Similar to Pseudomonas aeruginosa probable enoyl-CoA hydratase/isomerase Pa2013 TR:Q9I298 (EMBL:AE004627) (265 aa) fasta scores: E(): 2.1e-37, 41.06% id in 263 aa, and to Caulobacter crescentus enoyl-CoA hydratase/isomerase family protein Cc2169 TR:Q9A6C5 (EMBL:AE005888) (262 aa) fasta scores: E(): 3.4e-38, 44.22% id in 251 aa.
 0.721
BP3242
Conserved hypothetical protein; Similar to Rhizobium loti Mlr3007 protein TR:Q98H69 (EMBL:AP003000) (220 aa) fasta scores: E(): 4.6e-18, 36.71% id in 207 aa, and to Rhizobium meliloti hypothetical protein Smc04014 TR:CAC47377 (EMBL:AL591791) (208 aa) fasta scores: E(): 4.7e-17, 40.77% id in 206 aa.
  
 
 0.671
leuC-2
3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.645
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.643
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.
  
 
 0.637
BP2291
Similar to Pseudomonas putida tartrate dehydrogenase SW:TTUC_PSEPU (Q51945) (364 aa) fasta scores: E(): 2.7e-99, 67.77% id in 360 aa, and to Escherichia coli probable tartrate dehydrogenase YeaU or b1800 SW:TTUC_ECOLI (P76251) (361 aa) fasta scores: E(): 7.8e-104, 69.49% id in 354 aa.
  
 
 0.637
BP3849
Conserved hypothetical protein; Similar to Agrobacterium tumefaciens AGR_C_3858p TR:AAK87874 (EMBL:AE008129) (419 aa) fasta scores: E(): 8.2e-40, 34.09% id in 393 aa, and to Rhizobium meliloti putative conserved membrane-anchored protein SMB21182 TR:CAC49248 (EMBL:AL603645) (394 aa) fasta scores: E(): 1.5e-37, 33.58% id in 396 aa. Possible alternative translational start site; Belongs to the CoA-transferase III family.
 
 
  0.614
accA
Similar to Myxococcus xanthus acetyl-Coa Carboxylase biotin carboxylase subunit AccA TR:Q9FAF5 (EMBL:AB039884) (573 aa) fasta scores: E(): 8.6e-85, 46.667% id in 570 aa, and to Escherichia coli biotin carboxylase AccC or FabG or B3256 SW:ACCC_ECOLI (P24182) (449 aa) fasta scores: E(): 6.6e-76, 51.106% id in 452 aa. Also similar to BP0889 (50.224% identity in 446 aa overlap), and BP2996 (47.903% identity in 453 aa overlap).
 
  
 0.606
Your Current Organism:
Bordetella pertussis
NCBI taxonomy Id: 257313
Other names: B. pertussis Tohama I, Bordetella pertussis Tohama I
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