APT56189.1 protein (Roseomonas gilardii) - STRING interaction network

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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gene co-occurrence

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protein homology

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[Homology]

Score

APT56189.1

Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)

Predicted Functional Partners:

APT57535.1

0.827

APT59402.1

0.827

APT55844.1

0.823

APT59868.1

0.818

APT58499.1

0.817

APT57483.1

0.769

APT58332.1

0.669

APT56190.1

0.527

APT56191.1

0.517

APT57534.1

0.455

Your Current Organism:

Roseomonas gilardii

NCBI taxonomy Id: 257708
Other names: ATCC 49956, CCUG 33005, CIP 104026, R. gilardii, strain 5424

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APT55844.1	APT56189.1	RGI145_00600	RGI145_02730	Tricarboxylate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.823
APT55844.1	APT57483.1	RGI145_00600	RGI145_10630	Tricarboxylate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.507
APT56189.1	APT55844.1	RGI145_02730	RGI145_00600	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Tricarboxylate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.823
APT56189.1	APT56190.1	RGI145_02730	RGI145_02735	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	IclR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.527
APT56189.1	APT56191.1	RGI145_02730	RGI145_02740	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.517
APT56189.1	APT57483.1	RGI145_02730	RGI145_10630	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	0.769
APT56189.1	APT57534.1	RGI145_02730	RGI145_10915	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.455
APT56189.1	APT57535.1	RGI145_02730	RGI145_10920	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.827
APT56189.1	APT58332.1	RGI145_02730	RGI145_15650	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.669
APT56189.1	APT58499.1	RGI145_02730	RGI145_16665	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Tripartite tricarboxylate transporter TctA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.817
APT56189.1	APT59402.1	RGI145_02730	RGI145_15655	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.827
APT56189.1	APT59868.1	RGI145_02730	RGI145_21430	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Tripartite tricarboxylate transporter TctA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.818
APT56190.1	APT56189.1	RGI145_02735	RGI145_02730	IclR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.527
APT56190.1	APT56191.1	RGI145_02735	RGI145_02740	IclR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.757
APT56191.1	APT56189.1	RGI145_02740	RGI145_02730	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.517
APT56191.1	APT56190.1	RGI145_02740	RGI145_02735	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	IclR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.757
APT57483.1	APT55844.1	RGI145_10630	RGI145_00600	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Tricarboxylate transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.507
APT57483.1	APT56189.1	RGI145_10630	RGI145_02730	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Twin-arginine translocation pathway signal protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.769
APT57483.1	APT57535.1	RGI145_10630	RGI145_10920	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.502
APT57483.1	APT58332.1	RGI145_10630	RGI145_15650	Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.451

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Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.83

expected number of edges:

11

PPI enrichment p-value:

1.41e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017004

Cytochrome complex assembly

6 of 18

2.15

3.86

5.94e-09

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016667

Oxidoreductase activity, acting on a sulfur group of donors

5 of 32

1.82

2.27

8.33e-06

GO:0015036

Disulfide oxidoreductase activity

3 of 16

1.9

1.31

0.0025

GO:0047134

Protein-disulfide reductase (NAD(P)) activity

2 of 3

2.45

1.09

0.0102

GO:0016671

Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

2 of 4

2.33

1.04

0.0122

GO:0016491

Oxidoreductase activity

8 of 555

0.79

0.62

0.0019

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2886

Cytochrome complex assembly, and Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

8 of 26

2.12

5.25

5.31e-13

CL:2888

Cytochrome complex assembly, and Oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor

7 of 17

2.25

5.25

3.98e-12

CL:2890

Protein-disulfide reductase (NAD(P)) activity, and Thioredoxin, conserved site

5 of 6

2.55

4.5

1.97e-09

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-1015

Disulfide bond

3 of 11

2.07

1.59

0.00080

KW-0676

Redox-active center

3 of 19

1.83

1.36

0.0017

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13899

Thioredoxin-like

2 of 2

2.63

0.92

0.0211

PF08534

Redoxin

2 of 2

2.63

0.92

0.0211

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR017937

Thioredoxin, conserved site

4 of 6

2.45

2.98

2.05e-06

IPR013766

Thioredoxin domain

5 of 16

2.13

2.94

8.77e-07

IPR036249

Thioredoxin-like superfamily

6 of 50

1.71

2.44

8.77e-07

IPR013740

Redoxin

3 of 5

2.41

1.93

0.00024

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