Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
cycV,Heme exporter protein A (heme ABC transporter ATP-binding protein), cytochrome c biogenesis; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (200 aa)    
Predicted Functional Partners:
cycW,
Putative heme exporter protein B (heme ABC transporter membrane protein), cytochrome c biogenesis; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.
 0.999
cycZ,
Heme exporter protein C (ABC transporter permease component); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
 
 0.999
cycJ
CycJ cytochrome-c biosynthesis protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
 
 0.969
cycL
CycL cytochrome C-type biogenesis protein; Possible subunit of a heme lyase.
 
   
 0.851
cycY,
Putative cytochrome c biogenesis protein, thiol:disulfide interchange protein; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished.
 
   
 0.848
cycK
CycK cytochrome c-type synthesis protein.
 
   
 0.811
hemD
Uroporphyrinogen III synthase HEM4.
     
 0.780
lolD2
ATP-binding protein of ABC transporter, possibly involved in lipoprotein release; Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner.
  
     0.747
acnA
Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
       0.640
cycH
Cytochrome c-type biogenesis protein cycH; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished.
 
   
 0.635
Your Current Organism:
Rhodopseudomonas palustris CGA009
NCBI taxonomy Id: 258594
Other names: R. palustris CGA009, Rhodopseudomonas palustris str. CGA009, Rhodopseudomonas palustris strain CGA009
Server load: medium (44%) [HD]