node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPA1150 | his3 | RPA1150 | RPA3390 | Putative histidyl-tRNA synthetase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.925 |
RPA1150 | hisA | RPA1150 | RPA0312 | Putative histidyl-tRNA synthetase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | 0.919 |
RPA1150 | hisB | RPA1150 | RPA0309 | Putative histidyl-tRNA synthetase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | Imidazoleglycerol-phosphate dehydratase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | 0.906 |
RPA1150 | hisC | RPA1150 | RPA4439 | Putative histidyl-tRNA synthetase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | Putative histidinol-phosphate aminotransferase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.856 |
RPA1150 | hisD | RPA1150 | RPA4531 | Putative histidyl-tRNA synthetase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.923 |
RPA1150 | hisE1 | RPA1150 | RPA0314 | Putative histidyl-tRNA synthetase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | Putative phosphoribosyl-ATP pyrophosphatase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | 0.988 |
RPA1150 | hisE2 | RPA1150 | RPA4705 | Putative histidyl-tRNA synthetase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase. | 0.985 |
RPA1150 | hisF | RPA1150 | RPA0313 | Putative histidyl-tRNA synthetase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.921 |
RPA1150 | hisG | RPA1150 | RPA1149 | Putative histidyl-tRNA synthetase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
RPA1150 | hisH | RPA1150 | RPA0311 | Putative histidyl-tRNA synthetase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | Imidazoleglycerol-phosphate synthase, amidotransferase component; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.922 |
his3 | RPA1150 | RPA3390 | RPA1150 | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Putative histidyl-tRNA synthetase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | 0.925 |
his3 | hisA | RPA3390 | RPA0312 | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | 0.999 |
his3 | hisB | RPA3390 | RPA0309 | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Imidazoleglycerol-phosphate dehydratase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | 0.993 |
his3 | hisC | RPA3390 | RPA4439 | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Putative histidinol-phosphate aminotransferase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.946 |
his3 | hisD | RPA3390 | RPA4531 | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.981 |
his3 | hisE1 | RPA3390 | RPA0314 | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Putative phosphoribosyl-ATP pyrophosphatase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | 0.996 |
his3 | hisE2 | RPA3390 | RPA4705 | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | phosphoribosyl-AMP cyclohydrolase / phosphoribosyl-ATP pyrophosphohydrolase. | 0.995 |
his3 | hisF | RPA3390 | RPA0313 | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Imidazoleglycerol-phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
his3 | hisG | RPA3390 | RPA1149 | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.979 |
his3 | hisH | RPA3390 | RPA0311 | Phosphoribosyl c-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | Imidazoleglycerol-phosphate synthase, amidotransferase component; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.980 |