| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPA0613 | RPA0955 | RPA0613 | RPA0955 | NUDIX hydrolase. | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | 0.919 |
| RPA0613 | nadD | RPA0613 | RPA0165 | NUDIX hydrolase. | Possible nicotinate-nucleotide adneylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.909 |
| RPA0613 | surE | RPA0613 | RPA2841 | NUDIX hydrolase. | Survival protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.915 |
| RPA0955 | RPA0613 | RPA0955 | RPA0613 | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | NUDIX hydrolase. | 0.919 |
| RPA0955 | RPA1101 | RPA0955 | RPA1101 | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Putative cytidine deaminase. | 0.914 |
| RPA0955 | apt | RPA0955 | RPA4492 | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.926 |
| RPA0955 | guaB | RPA0955 | RPA2200 | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.920 |
| RPA0955 | guaC | RPA0955 | RPA4561 | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. | 0.915 |
| RPA0955 | nadD | RPA0955 | RPA0165 | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Possible nicotinate-nucleotide adneylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.915 |
| RPA0955 | purA | RPA0955 | RPA4295 | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.914 |
| RPA0955 | purB | RPA0955 | RPA3817 | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Adenylosuccinate lyase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.915 |
| RPA0955 | surE | RPA0955 | RPA2841 | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Survival protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.916 |
| RPA0955 | tmk | RPA0955 | RPA2775 | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.939 |
| RPA1101 | RPA0955 | RPA1101 | RPA0955 | Putative cytidine deaminase. | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | 0.914 |
| RPA1101 | surE | RPA1101 | RPA2841 | Putative cytidine deaminase. | Survival protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.905 |
| apt | RPA0955 | RPA4492 | RPA0955 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative 5`-nucleotidase family protein; Belongs to the 5'-nucleotidase family. | 0.926 |
| apt | guaB | RPA4492 | RPA2200 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.504 |
| apt | purA | RPA4492 | RPA4295 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. | 0.841 |
| apt | purB | RPA4492 | RPA3817 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Adenylosuccinate lyase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.986 |
| apt | surE | RPA4492 | RPA2841 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Survival protein surE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. | 0.934 |