close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hypAHydrogenase formation/expression protein hypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (113 aa)    
Predicted Functional Partners:
hupL
Hydrogenase large chain; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.987
hupK
Putative hydrogenase expression/formation protein hupK.
 
 
 0.986
hypF
Hydrogenase maturation protein hypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
  
 0.986
hypB
Hydrogenase expression/formation protein hypB.
 
 
 0.984
hupH
Hydrogenase expression/formation protein hupH; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished.
 
  
 0.980
hypC
Putative hypC.
 
  
 0.973
hypD
Hydrogenase expression/formation protein hypD; Belongs to the HypD family.
 
  
 0.972
hypE
Hydrogenase expression/formation protein hypE.
 
  
 0.968
hupS
Uptake hydrogenase regulatory protein hupV pseudogene, frameshifted; Authentic frameshift, hupV pseudogene.
 
  
 0.955
hupJ
Putative hydrogenase expression/formation protein hupJ.
 
  
 0.938
Your Current Organism:
Rhodopseudomonas palustris CGA009
NCBI taxonomy Id: 258594
Other names: R. palustris CGA009, Rhodopseudomonas palustris str. CGA009, Rhodopseudomonas palustris strain CGA009
Server load: low (40%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.