node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPA1801 | RPA1802 | RPA1801 | RPA1802 | Conserved hypothetical protein. | Conserved hypothetical protein; COGs COG0389. | 0.993 |
RPA1801 | dnaE2 | RPA1801 | RPA1803 | Conserved hypothetical protein. | Putative DNA polymerase III alpha chain; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.913 |
RPA1801 | lexA | RPA1801 | RPA2903 | Conserved hypothetical protein. | SOS response transcriptional repressor, lexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.406 |
RPA1802 | RPA1801 | RPA1802 | RPA1801 | Conserved hypothetical protein; COGs COG0389. | Conserved hypothetical protein. | 0.993 |
RPA1802 | RPA2546 | RPA1802 | RPA2546 | Conserved hypothetical protein; COGs COG0389. | FKBP-type peptidyl-prolyl cis-trans isomerase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | 0.685 |
RPA1802 | RPA3650 | RPA1802 | RPA3650 | Conserved hypothetical protein; COGs COG0389. | ATP-dependent DNA ligase. | 0.706 |
RPA1802 | RPA4721 | RPA1802 | RPA4721 | Conserved hypothetical protein; COGs COG0389. | possible+E2677 pyruvate-flavodoxin oxidoreductase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | 0.805 |
RPA1802 | dnaE2 | RPA1802 | RPA1803 | Conserved hypothetical protein; COGs COG0389. | Putative DNA polymerase III alpha chain; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.954 |
RPA1802 | dnaN | RPA1802 | RPA0002 | Conserved hypothetical protein; COGs COG0389. | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.968 |
RPA1802 | ftsW | RPA1802 | RPA3531 | Conserved hypothetical protein; COGs COG0389. | Putative cell division protein ftsW; Belongs to the SEDS family. | 0.758 |
RPA1802 | lexA | RPA1802 | RPA2903 | Conserved hypothetical protein; COGs COG0389. | SOS response transcriptional repressor, lexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.823 |
RPA1802 | polA | RPA1802 | RPA4723 | Conserved hypothetical protein; COGs COG0389. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.755 |
RPA1802 | recA | RPA1802 | RPA3851 | Conserved hypothetical protein; COGs COG0389. | Recombination protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.726 |
RPA2546 | RPA1802 | RPA2546 | RPA1802 | FKBP-type peptidyl-prolyl cis-trans isomerase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | Conserved hypothetical protein; COGs COG0389. | 0.685 |
RPA2546 | ftsW | RPA2546 | RPA3531 | FKBP-type peptidyl-prolyl cis-trans isomerase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | Putative cell division protein ftsW; Belongs to the SEDS family. | 0.641 |
RPA3650 | RPA1802 | RPA3650 | RPA1802 | ATP-dependent DNA ligase. | Conserved hypothetical protein; COGs COG0389. | 0.706 |
RPA3650 | dnaE2 | RPA3650 | RPA1803 | ATP-dependent DNA ligase. | Putative DNA polymerase III alpha chain; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.582 |
RPA3650 | dnaN | RPA3650 | RPA0002 | ATP-dependent DNA ligase. | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.977 |
RPA3650 | polA | RPA3650 | RPA4723 | ATP-dependent DNA ligase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.953 |
RPA3650 | recA | RPA3650 | RPA3851 | ATP-dependent DNA ligase. | Recombination protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.538 |