cyp199a2 protein (Rhodopseudomonas palustris CGA009)

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cyp199a2

Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate. (412 aa)

Predicted Functional Partners:

vanB

0.961

phbH

0.945

thcC

0.932

RPA3338

0.918

hbaA

0.904

RPA1788

0.900

mcyE

0.865

rnd

0.757

pntA

0.741

hbaH

0.740

Your Current Organism:

Rhodopseudomonas palustris CGA009

NCBI taxonomy Id: 258594
Other names: R. palustris CGA009, Rhodopseudomonas palustris str. CGA009, Rhodopseudomonas palustris strain CGA009

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
RPA1788	cyp199a2	RPA1788	RPA1871	Possible 4-hydroxybenzoyl-CoA thioesterase.	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	0.900
RPA1788	hbaA	RPA1788	RPA0669	Possible 4-hydroxybenzoyl-CoA thioesterase.	4-hydroxybenzoate-CoA ligase; Catalyzes the ligation of 4-hydroxybenzoate, benzoate or cyclohex-1,4-dienecarboxylate and CoA at the expense of ATP. The enzyme shows low activity towards cyclo-2,5-dienecarboxylate, 4- fluorobenzoate, 4-chlorobenzoate and 2-methoxybenzoate. Belongs to the ATP-dependent AMP-binding enzyme family. Benzoate-CoA ligase subfamily.	0.948
RPA1788	mcyE	RPA1788	RPA3339	Possible 4-hydroxybenzoyl-CoA thioesterase.	Possible McyE polykeitde synthase and peptide synthetase (AF183408).	0.594
RPA1788	phbH	RPA1788	RPA1781	Possible 4-hydroxybenzoyl-CoA thioesterase.	4-hydroxybenzoate hydroxylase (4-hydroxybenzoate-3-monooxygenase).	0.922
RPA3338	cyp199a2	RPA3338	RPA1871	Possible Condensation domain, peptide synthetase.	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	0.918
RPA3338	hbaA	RPA3338	RPA0669	Possible Condensation domain, peptide synthetase.	4-hydroxybenzoate-CoA ligase; Catalyzes the ligation of 4-hydroxybenzoate, benzoate or cyclohex-1,4-dienecarboxylate and CoA at the expense of ATP. The enzyme shows low activity towards cyclo-2,5-dienecarboxylate, 4- fluorobenzoate, 4-chlorobenzoate and 2-methoxybenzoate. Belongs to the ATP-dependent AMP-binding enzyme family. Benzoate-CoA ligase subfamily.	0.513
RPA3338	mcyE	RPA3338	RPA3339	Possible Condensation domain, peptide synthetase.	Possible McyE polykeitde synthase and peptide synthetase (AF183408).	0.995
cyp199a2	RPA1788	RPA1871	RPA1788	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	Possible 4-hydroxybenzoyl-CoA thioesterase.	0.900
cyp199a2	RPA3338	RPA1871	RPA3338	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	Possible Condensation domain, peptide synthetase.	0.918
cyp199a2	hbaA	RPA1871	RPA0669	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	4-hydroxybenzoate-CoA ligase; Catalyzes the ligation of 4-hydroxybenzoate, benzoate or cyclohex-1,4-dienecarboxylate and CoA at the expense of ATP. The enzyme shows low activity towards cyclo-2,5-dienecarboxylate, 4- fluorobenzoate, 4-chlorobenzoate and 2-methoxybenzoate. Belongs to the ATP-dependent AMP-binding enzyme family. Benzoate-CoA ligase subfamily.	0.904
cyp199a2	hbaH	RPA1871	RPA0665	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	Putative ABC transporter subunit, ATP-binding component.	0.740
cyp199a2	mcyE	RPA1871	RPA3339	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	Possible McyE polykeitde synthase and peptide synthetase (AF183408).	0.865
cyp199a2	phbH	RPA1871	RPA1781	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	4-hydroxybenzoate hydroxylase (4-hydroxybenzoate-3-monooxygenase).	0.945
cyp199a2	pntA	RPA1871	RPA4181	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	Nicotinamide nucleotide transhydrogenase, subunit alpha2.	0.741
cyp199a2	rnd	RPA1871	RPA3045	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	Ribonuclease D; Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides; Belongs to the RNase D family.	0.757
cyp199a2	thcC	RPA1871	RPA1872	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	Rhodocoxin; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished.	0.932
cyp199a2	vanB	RPA1871	RPA3621	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	Putative vanillate O-demethylase oxidoreductase.	0.961
hbaA	RPA1788	RPA0669	RPA1788	4-hydroxybenzoate-CoA ligase; Catalyzes the ligation of 4-hydroxybenzoate, benzoate or cyclohex-1,4-dienecarboxylate and CoA at the expense of ATP. The enzyme shows low activity towards cyclo-2,5-dienecarboxylate, 4- fluorobenzoate, 4-chlorobenzoate and 2-methoxybenzoate. Belongs to the ATP-dependent AMP-binding enzyme family. Benzoate-CoA ligase subfamily.	Possible 4-hydroxybenzoyl-CoA thioesterase.	0.948
hbaA	RPA3338	RPA0669	RPA3338	4-hydroxybenzoate-CoA ligase; Catalyzes the ligation of 4-hydroxybenzoate, benzoate or cyclohex-1,4-dienecarboxylate and CoA at the expense of ATP. The enzyme shows low activity towards cyclo-2,5-dienecarboxylate, 4- fluorobenzoate, 4-chlorobenzoate and 2-methoxybenzoate. Belongs to the ATP-dependent AMP-binding enzyme family. Benzoate-CoA ligase subfamily.	Possible Condensation domain, peptide synthetase.	0.513
hbaA	cyp199a2	RPA0669	RPA1871	4-hydroxybenzoate-CoA ligase; Catalyzes the ligation of 4-hydroxybenzoate, benzoate or cyclohex-1,4-dienecarboxylate and CoA at the expense of ATP. The enzyme shows low activity towards cyclo-2,5-dienecarboxylate, 4- fluorobenzoate, 4-chlorobenzoate and 2-methoxybenzoate. Belongs to the ATP-dependent AMP-binding enzyme family. Benzoate-CoA ligase subfamily.	Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate.	0.904

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