Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
RPA2895Possible small heat shock protein; Belongs to the small heat shock protein (HSP20) family. (166 aa)    
Predicted Functional Partners:
clpB
Endopeptidase Clp: ATP-binding subunit B, clpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the C [...]
 
 
 0.802
clpA
Endopeptidase Clp: ATP-binding chain A; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished; Belongs to the ClpA/ClpB family.
  
 
 0.771
dnaK
Heat shock protein DnaK (70); Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.664
grpE
Possible heat shock protein (HSP-70 COFACTOR), grpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction c [...]
  
 
 0.592
RPA2894
Conserved hypothetical protein.
       0.567
RPA0369
Aminoacyl-tRNA synthetase, class I:ATP-binding region, ATPase-like.
  
 
 0.539
htpG
Heat shock protein HtpG; Molecular chaperone. Has ATPase activity.
  
 
 0.539
hslV
Heat shock protein HslV, proteasome-related peptidase subunit; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.
  
  
 0.532
RPA0253
DUF589; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished.
   
    0.530
bchJ
Putative 4-vinyl protochlorophyllide reductase; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished.
   
    0.530
Your Current Organism:
Rhodopseudomonas palustris CGA009
NCBI taxonomy Id: 258594
Other names: R. palustris CGA009, Rhodopseudomonas palustris str. CGA009, Rhodopseudomonas palustris strain CGA009
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