| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPA0877 | hflC | RPA0877 | RPA3490 | Conserved hypothetical protein; COGs COG1585. | Putative hflC protein; HflC and HflK could regulate a protease. | 0.615 |
| RPA0877 | hflK | RPA0877 | RPA3491 | Conserved hypothetical protein; COGs COG1585. | Putative protease subunit hflK; HflC and HflK could encode or regulate a protease. | 0.609 |
| RPA3489 | hflC | RPA3489 | RPA3490 | Conserved hypothetical protein. | Putative hflC protein; HflC and HflK could regulate a protease. | 0.665 |
| RPA3489 | hflK | RPA3489 | RPA3491 | Conserved hypothetical protein. | Putative protease subunit hflK; HflC and HflK could encode or regulate a protease. | 0.654 |
| RPA3489 | thyA | RPA3489 | RPA3493 | Conserved hypothetical protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.489 |
| ampG | hflC | RPA0619 | RPA3490 | Putative MFS transporter and signal transducer AmpG; E. coli beta lactamase (AmpC) regulator. | Putative hflC protein; HflC and HflK could regulate a protease. | 0.794 |
| dnaK | ftsH | RPA0333 | RPA1126 | Heat shock protein DnaK (70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Metalloprotease (cell division protein) FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.918 |
| dnaK | ftsZ | RPA0333 | RPA3522 | Heat shock protein DnaK (70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.578 |
| dnaK | hflC | RPA0333 | RPA3490 | Heat shock protein DnaK (70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Putative hflC protein; HflC and HflK could regulate a protease. | 0.611 |
| dnaK | hflK | RPA0333 | RPA3491 | Heat shock protein DnaK (70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | Putative protease subunit hflK; HflC and HflK could encode or regulate a protease. | 0.548 |
| dnaK | nuoCD | RPA0333 | RPA4262 | Heat shock protein DnaK (70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | NADH-ubiquinone dehydrogenase chain C,D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family. | 0.759 |
| ftsH | dnaK | RPA1126 | RPA0333 | Metalloprotease (cell division protein) FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Heat shock protein DnaK (70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.918 |
| ftsH | ftsZ | RPA1126 | RPA3522 | Metalloprotease (cell division protein) FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | 0.574 |
| ftsH | hflC | RPA1126 | RPA3490 | Metalloprotease (cell division protein) FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Putative hflC protein; HflC and HflK could regulate a protease. | 0.968 |
| ftsH | hflK | RPA1126 | RPA3491 | Metalloprotease (cell division protein) FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | Putative protease subunit hflK; HflC and HflK could encode or regulate a protease. | 0.983 |
| ftsH | hflX | RPA1126 | RPA2598 | Metalloprotease (cell division protein) FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | GTP binding protein-like; GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. | 0.722 |
| ftsH | nuoCD | RPA1126 | RPA4262 | Metalloprotease (cell division protein) FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | NADH-ubiquinone dehydrogenase chain C,D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the N-terminal section; belongs to the complex I 30 kDa subunit family. | 0.558 |
| ftsZ | dnaK | RPA3522 | RPA0333 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Heat shock protein DnaK (70); Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.578 |
| ftsZ | ftsH | RPA3522 | RPA1126 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Metalloprotease (cell division protein) FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. | 0.574 |
| ftsZ | hflC | RPA3522 | RPA3490 | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. | Putative hflC protein; HflC and HflK could regulate a protease. | 0.628 |