node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
RPA1802 | RPA3650 | RPA1802 | RPA3650 | Conserved hypothetical protein; COGs COG0389. | ATP-dependent DNA ligase. | 0.706 |
RPA1802 | dnaN | RPA1802 | RPA0002 | Conserved hypothetical protein; COGs COG0389. | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.968 |
RPA1802 | polA | RPA1802 | RPA4723 | Conserved hypothetical protein; COGs COG0389. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.755 |
RPA3650 | RPA1802 | RPA3650 | RPA1802 | ATP-dependent DNA ligase. | Conserved hypothetical protein; COGs COG0389. | 0.706 |
RPA3650 | RPA3785 | RPA3650 | RPA3785 | ATP-dependent DNA ligase. | DUF72; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | 0.767 |
RPA3650 | dnaN | RPA3650 | RPA0002 | ATP-dependent DNA ligase. | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.977 |
RPA3650 | gmhB | RPA3650 | RPA3988 | ATP-dependent DNA ligase. | Putative phosphatase; Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate (beta-HBP) intermediate into D-glycero-beta-D-manno-heptose 1-phosphate by removing the phosphate group at the C-7 position. Also catalyzes the dephosphorylation of D-glycero-alpha-D-manno-heptose 1,7-bisphosphate in vitro. | 0.738 |
RPA3650 | ku | RPA3650 | RPA0386 | ATP-dependent DNA ligase. | Ku domain; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.951 |
RPA3650 | ku-2 | RPA3650 | RPA3651 | ATP-dependent DNA ligase. | Ku domain; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.976 |
RPA3650 | polA | RPA3650 | RPA4723 | ATP-dependent DNA ligase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.953 |
RPA3650 | xthA1 | RPA3650 | RPA0281 | ATP-dependent DNA ligase. | Possible exodeoxyribonuclease III. | 0.752 |
RPA3650 | xthA2 | RPA3650 | RPA2861 | ATP-dependent DNA ligase. | Exodeoxyribonuclease III. | 0.904 |
RPA3650 | xthA3 | RPA3650 | RPA3307 | ATP-dependent DNA ligase. | Putative exonuclease III. | 0.960 |
RPA3785 | RPA3650 | RPA3785 | RPA3650 | DUF72; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | ATP-dependent DNA ligase. | 0.767 |
RPA3785 | ku | RPA3785 | RPA0386 | DUF72; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | Ku domain; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.581 |
RPA3785 | ku-2 | RPA3785 | RPA3651 | DUF72; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | Ku domain; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. | 0.606 |
dnaN | RPA1802 | RPA0002 | RPA1802 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Conserved hypothetical protein; COGs COG0389. | 0.968 |
dnaN | RPA3650 | RPA0002 | RPA3650 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | ATP-dependent DNA ligase. | 0.977 |
dnaN | polA | RPA0002 | RPA4723 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.996 |
dnaN | xthA1 | RPA0002 | RPA0281 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Possible exodeoxyribonuclease III. | 0.806 |