| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| RPA0613 | cobB-2 | RPA0613 | RPA2524 | NUDIX hydrolase. | Sir2 family, possible ADP ribosyltransferase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | 0.928 |
| RPA0613 | mazG | RPA0613 | RPA2811 | NUDIX hydrolase. | Possible mazG. | 0.912 |
| RPA0613 | nadD | RPA0613 | RPA0165 | NUDIX hydrolase. | Possible nicotinate-nucleotide adneylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.909 |
| RPA0613 | nadE | RPA0613 | RPA1986 | NUDIX hydrolase. | NH3-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.913 |
| RPA0613 | nadK | RPA0613 | RPA3374 | NUDIX hydrolase. | DUF15 protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.904 |
| RPA0613 | pntA | RPA0613 | RPA4181 | NUDIX hydrolase. | Nicotinamide nucleotide transhydrogenase, subunit alpha2. | 0.900 |
| RPA0613 | pntA-2 | RPA0613 | RPA4182 | NUDIX hydrolase. | Nicotinamide nucleotide transhydrogenase, subunit alpha1; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | 0.900 |
| RPA0613 | pntB | RPA0613 | RPA4180 | NUDIX hydrolase. | Nicotinamide nucleotide transhydrogenase, subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.900 |
| cobB-2 | RPA0613 | RPA2524 | RPA0613 | Sir2 family, possible ADP ribosyltransferase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | NUDIX hydrolase. | 0.928 |
| cobB-2 | mazG | RPA2524 | RPA2811 | Sir2 family, possible ADP ribosyltransferase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | Possible mazG. | 0.902 |
| cobB-2 | nadD | RPA2524 | RPA0165 | Sir2 family, possible ADP ribosyltransferase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | Possible nicotinate-nucleotide adneylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). | 0.937 |
| cobB-2 | nadE | RPA2524 | RPA1986 | Sir2 family, possible ADP ribosyltransferase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | NH3-dependent NAD synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.954 |
| cobB-2 | nadK | RPA2524 | RPA3374 | Sir2 family, possible ADP ribosyltransferase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | DUF15 protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.927 |
| cobB-2 | pntA | RPA2524 | RPA4181 | Sir2 family, possible ADP ribosyltransferase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | Nicotinamide nucleotide transhydrogenase, subunit alpha2. | 0.904 |
| cobB-2 | pntA-2 | RPA2524 | RPA4182 | Sir2 family, possible ADP ribosyltransferase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | Nicotinamide nucleotide transhydrogenase, subunit alpha1; Observed by proteomics; Citation: Proteomics from VerBerkmoes et al. (2003) unpublished. | 0.904 |
| cobB-2 | pntB | RPA2524 | RPA4180 | Sir2 family, possible ADP ribosyltransferase; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form; Belongs to the sirtuin family. Class U subfamily. | Nicotinamide nucleotide transhydrogenase, subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. | 0.902 |
| cyp199a2 | hbaH | RPA1871 | RPA0665 | Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate. | Putative ABC transporter subunit, ATP-binding component. | 0.740 |
| cyp199a2 | pntA | RPA1871 | RPA4181 | Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate. | Nicotinamide nucleotide transhydrogenase, subunit alpha2. | 0.741 |
| hbaH | cyp199a2 | RPA0665 | RPA1871 | Putative ABC transporter subunit, ATP-binding component. | Putative cytochrome P450; The oxidative demethylation of 4-methoxybenzoate requires the participation of the monooxygenase CYP199A2, the ferredoxin-like protein ThcC/RPA1872 and a ferredoxin reductase to mediate the transfer of electrons from NADH to CYP199A2. It is also active with 4- ethylbenzoate. | 0.740 |
| hbaH | pntA | RPA0665 | RPA4181 | Putative ABC transporter subunit, ATP-binding component. | Nicotinamide nucleotide transhydrogenase, subunit alpha2. | 0.741 |